HIV-1感染患者的免疫激活与色氨酸减少

Immune activation and decreased tryptophan in patients with HIV-1 infection.

作者信息

Fuchs D, Forsman A, Hagberg L, Larsson M, Norkrans G, Reibnegger G, Werner E R, Wachter H

机构信息

Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Austria.

出版信息

J Interferon Res. 1990 Dec;10(6):599-603. doi: 10.1089/jir.1990.10.599.

DOI:10.1089/jir.1990.10.599

PMID:2128302

Abstract

We compared tryptophan, neopterin, and interferon-gamma (IFN-gamma) concentrations in serum and cerebrospinal fluid (CSF) of 22 patients with human immunodeficiency virus type 1 (HIV-1) infection. Tryptophan levels were found to be decreased in CSF and serum of patients whereas neopterin levels in CSF and serum and serum IFN-gamma concentrations were increased compared to healthy HIV-1 seronegatives. Tryptophan concentrations correlated negatively to neopterin concentrations, and serum neopterin concentrations correlated positively to IFN-gamma concentrations. Thus, decrease of tryptophan levels is associated with chronic immune stimulation in patients with HIV-1 infection. From the data it appears that reduced tryptophan in patients may result from induction of indoleamine (2,3)-dioxygenase by IFN-gamma.

摘要

我们比较了22例1型人类免疫缺陷病毒（HIV-1）感染患者血清和脑脊液（CSF）中的色氨酸、新蝶呤和干扰素-γ（IFN-γ）浓度。结果发现，患者脑脊液和血清中的色氨酸水平降低，而与健康的HIV-1血清阴性者相比，脑脊液和血清中的新蝶呤水平以及血清IFN-γ浓度升高。色氨酸浓度与新蝶呤浓度呈负相关，血清新蝶呤浓度与IFN-γ浓度呈正相关。因此，色氨酸水平降低与HIV-1感染患者的慢性免疫刺激有关。从数据来看，患者色氨酸减少可能是由于IFN-γ诱导吲哚胺（2,3）-双加氧酶所致。