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靶向癌症治疗的加速途径。

An accelerated pathway for targeted cancer therapies.

机构信息

Engelberg Center for Health Care Reform, Brookings Institution, Washington DC, USA.

出版信息

Nat Rev Drug Discov. 2011 Feb;10(2):79-80. doi: 10.1038/nrd3360.

DOI:10.1038/nrd3360
PMID:21283090
Abstract

A well-defined pathway for the accelerated development and approval of targeted cancer therapies and companion diagnostics would reduce uncertainty, improve efficiency in development and provide an effective incentive for developers.

摘要

一个明确的途径,用于加速靶向癌症疗法和伴随诊断的开发和批准,将减少不确定性,提高开发效率,并为开发者提供有效的激励。

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An accelerated pathway for targeted cancer therapies.靶向癌症治疗的加速途径。
Nat Rev Drug Discov. 2011 Feb;10(2):79-80. doi: 10.1038/nrd3360.
2
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3
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Future Med Chem. 2013 Feb;5(2):123.
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[Forefront of Cancer Targeting Therapy].
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Are targeted therapies really targeted?靶向疗法真的是靶向的吗?
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CARF enrichment promotes epithelial-mesenchymal transition via Wnt/β-catenin signaling: its clinical relevance and potential as a therapeutic target.

本文引用的文献

1
Clinical trial designs for predictive biomarker validation: theoretical considerations and practical challenges.预测性生物标志物验证的临床试验设计:理论考量与实际挑战。
J Clin Oncol. 2009 Aug 20;27(24):4027-34. doi: 10.1200/JCO.2009.22.3701. Epub 2009 Jul 13.
2
I-SPY 2: an adaptive breast cancer trial design in the setting of neoadjuvant chemotherapy.I-SPY 2:新辅助化疗背景下的适应性乳腺癌试验设计
Clin Pharmacol Ther. 2009 Jul;86(1):97-100. doi: 10.1038/clpt.2009.68. Epub 2009 May 13.
3
Randomized phase III clinical trial designs for targeted agents.
CARF富集通过Wnt/β-连环蛋白信号通路促进上皮-间质转化:其临床相关性及作为治疗靶点的潜力
Oncogenesis. 2018 May 11;7(5):39. doi: 10.1038/s41389-018-0048-4.
4
Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice.具有小鼠口服生物利用度的人乳酸脱氢酶细胞活性羟内酰胺抑制剂
ACS Med Chem Lett. 2016 Aug 26;7(10):896-901. doi: 10.1021/acsmedchemlett.6b00190. eCollection 2016 Oct 13.
5
Bayesian Two-stage Biomarker-based Adaptive Design for Targeted Therapy Development.用于靶向治疗开发的基于贝叶斯两阶段生物标志物的适应性设计
Stat Biosci. 2016 Jun;8(1):99-128. doi: 10.1007/s12561-014-9124-2. Epub 2014 Dec 4.
6
Optimal design of trials to demonstrate the utility of genomically-guided therapy: Putting Precision Cancer Medicine to the test.证明基因组指导疗法效用的试验的优化设计:对精准癌症医学进行检验。
Mol Oncol. 2015 May;9(5):940-50. doi: 10.1016/j.molonc.2014.06.014. Epub 2014 Jul 15.
7
Detection of somatic mutations in tumors using unaligned clonal sequencing data.利用未比对的克隆测序数据检测肿瘤中的体细胞突变。
Lab Invest. 2014 Oct;94(10):1173-83. doi: 10.1038/labinvest.2014.96. Epub 2014 Jul 28.
8
Translational control of cell growth and malignancy by the CPEBs.CPEBs 对细胞生长和恶性转化的翻译调控
Nat Rev Cancer. 2013 Apr;13(4):283-90. doi: 10.1038/nrc3485. Epub 2013 Feb 28.
9
Assessing the efficacy of molecularly targeted agents on cell line-based platforms by using system identification.基于系统辨识评估基于细胞系的平台上分子靶向药物的疗效。
BMC Genomics. 2012;13 Suppl 6(Suppl 6):S11. doi: 10.1186/1471-2164-13-S6-S11. Epub 2012 Oct 26.
10
Clinical trials in the era of personalized oncology.个体化肿瘤学时代的临床试验。
CA Cancer J Clin. 2011 Nov-Dec;61(6):365-81. doi: 10.3322/caac.20135. Epub 2011 Oct 27.
靶向药物的随机III期临床试验设计
Clin Cancer Res. 2008 Jul 15;14(14):4358-67. doi: 10.1158/1078-0432.CCR-08-0288.
4
Strategic paths for biomarker qualification.生物标志物鉴定的战略路径。
Toxicology. 2008 Mar 20;245(3):219-23. doi: 10.1016/j.tox.2007.12.023. Epub 2008 Jan 6.
5
Biomarker-adaptive threshold design: a procedure for evaluating treatment with possible biomarker-defined subset effect.生物标志物适应性阈值设计:一种评估具有可能由生物标志物定义的亚组效应的治疗方法。
J Natl Cancer Inst. 2007 Jul 4;99(13):1036-43. doi: 10.1093/jnci/djm022. Epub 2007 Jun 27.
6
Evaluating the efficiency of targeted designs for randomized clinical trials.评估随机临床试验靶向设计的效率。
Clin Cancer Res. 2004 Oct 15;10(20):6759-63. doi: 10.1158/1078-0432.CCR-04-0496.