• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

组蛋白去乙酰化酶抑制剂增强基于痘病毒的溶瘤作用。

Enhancement of vaccinia virus based oncolysis with histone deacetylase inhibitors.

机构信息

Center for Cancer Therapeutics, Ottawa Hospital Research Institute, Ontario, Canada.

出版信息

PLoS One. 2010 Dec 30;5(12):e14462. doi: 10.1371/journal.pone.0014462.

DOI:10.1371/journal.pone.0014462
PMID:21283510
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3012680/
Abstract

Histone deacetylase inhibitors (HDI) dampen cellular innate immune response by decreasing interferon production and have been shown to increase the growth of vesicular stomatitis virus and HSV. As attenuated tumour-selective oncolytic vaccinia viruses (VV) are already undergoing clinical evaluation, the goal of this study is to determine whether HDI can also enhance the potency of these poxviruses in infection-resistant cancer cell lines. Multiple HDIs were tested and Trichostatin A (TSA) was found to potently enhance the spread and replication of a tumour selective vaccinia virus in several infection-resistant cancer cell lines. TSA significantly decreased the number of lung metastases in a syngeneic B16F10LacZ lung metastasis model yet did not increase the replication of vaccinia in normal tissues. The combination of TSA and VV increased survival of mice harbouring human HCT116 colon tumour xenografts as compared to mice treated with either agent alone. We conclude that TSA can selectively and effectively enhance the replication and spread of oncolytic vaccinia virus in cancer cells.

摘要

组蛋白去乙酰化酶抑制剂（HDIs）通过减少干扰素的产生来抑制细胞固有免疫反应，并且已被证明可以增加单纯疱疹病毒和水疱性口炎病毒的生长。由于减毒的肿瘤选择性溶瘤痘病毒（VV）已经在进行临床评估，因此本研究的目的是确定 HDI 是否也可以增强这些痘病毒在感染抗性癌细胞系中的效力。测试了多种 HDI，发现 Trichostatin A（TSA）可强效增强几种感染抗性癌细胞系中肿瘤选择性痘病毒的传播和复制。TSA 显著减少了 B16F10LacZ 肺转移模型中的肺转移数量，但并未增加痘病毒在正常组织中的复制。与单独用任何一种药物治疗的小鼠相比， TSA 和 VV 的联合使用增加了携带人 HCT116 结肠肿瘤异种移植物的小鼠的存活率。我们得出结论，TSA 可以选择性和有效地增强溶瘤痘病毒在癌细胞中的复制和传播。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/040e/3012680/3464454d919c/pone.0014462.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/040e/3012680/6b98bea96b55/pone.0014462.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/040e/3012680/e87db6622d09/pone.0014462.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/040e/3012680/8d1464928516/pone.0014462.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/040e/3012680/3464454d919c/pone.0014462.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/040e/3012680/6b98bea96b55/pone.0014462.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/040e/3012680/e87db6622d09/pone.0014462.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/040e/3012680/8d1464928516/pone.0014462.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/040e/3012680/3464454d919c/pone.0014462.g004.jpg

相似文献

1
Enhancement of vaccinia virus based oncolysis with histone deacetylase inhibitors.组蛋白去乙酰化酶抑制剂增强基于痘病毒的溶瘤作用。
PLoS One. 2010 Dec 30;5(12):e14462. doi: 10.1371/journal.pone.0014462.
2
Histone deacetylase inhibitor boosts anticancer potential of fusogenic oncolytic vaccinia virus by enhancing cell-cell fusion.组蛋白去乙酰化酶抑制剂通过增强细胞融合增强融合溶瘤痘病毒的抗癌潜力。
Cancer Sci. 2024 Feb;115(2):600-610. doi: 10.1111/cas.16032. Epub 2023 Nov 30.
3
Potentiating Oncolytic Virus-Induced Immune-Mediated Tumor Cell Killing Using Histone Deacetylase Inhibition.使用组蛋白去乙酰化酶抑制增强溶瘤病毒诱导的免疫介导的肿瘤细胞杀伤。
Mol Ther. 2019 Jun 5;27(6):1139-1152. doi: 10.1016/j.ymthe.2019.04.008. Epub 2019 Apr 14.
4
Histone deacetylase inhibitors potentiate vesicular stomatitis virus oncolysis in prostate cancer cells by modulating NF-κB-dependent autophagy.组蛋白去乙酰化酶抑制剂通过调节NF-κB依赖性自噬增强水泡性口炎病毒对前列腺癌细胞的溶瘤作用。
J Virol. 2014 Mar;88(5):2927-40. doi: 10.1128/JVI.03406-13. Epub 2013 Dec 26.
5
Oncolytic and immunologic cancer therapy with GM-CSF-armed vaccinia virus of Tian Tan strain Guang9.Tian Tan 株 GM-CSF 武装痘苗病毒的溶瘤和免疫肿瘤治疗。
Cancer Lett. 2016 Mar 28;372(2):251-7. doi: 10.1016/j.canlet.2016.01.025. Epub 2016 Jan 21.
6
Chemical targeting of the innate antiviral response by histone deacetylase inhibitors renders refractory cancers sensitive to viral oncolysis.组蛋白去乙酰化酶抑制剂对先天性抗病毒反应的化学靶向作用使难治性癌症对病毒溶瘤敏感。
Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):14981-6. doi: 10.1073/pnas.0803988105. Epub 2008 Sep 24.
7
Anti-tumour activity of oncolytic Western Reserve vaccinia viruses in canine tumour cell lines, xenografts, and fresh tumour biopsies.溶瘤性西储氏牛痘病毒在犬肿瘤细胞系、异种移植物和新鲜肿瘤活检中的抗肿瘤活性。
Vet Comp Oncol. 2016 Dec;14(4):395-408. doi: 10.1111/vco.12119. Epub 2014 Oct 10.
8
Targeting of interferon-beta to produce a specific, multi-mechanistic oncolytic vaccinia virus.靶向干扰素-β以产生一种特异性的、多机制的溶瘤痘苗病毒。
PLoS Med. 2007 Dec;4(12):e353. doi: 10.1371/journal.pmed.0040353.
9
Histone deacetylase 6 inhibition enhances oncolytic viral replication in glioma.组蛋白去乙酰化酶6抑制作用增强了溶瘤病毒在胶质瘤中的复制。
J Clin Invest. 2015 Nov 2;125(11):4269-80. doi: 10.1172/JCI80713. Epub 2015 Oct 20.
10
IL-24-Armed Oncolytic Vaccinia Virus Exerts Potent Antitumor Effects via Multiple Pathways in Colorectal Cancer.IL-24 武装溶瘤痘苗病毒通过多种途径在结直肠癌中发挥强大的抗肿瘤作用。
Oncol Res. 2021 Mar 16;28(6):579-590. doi: 10.3727/096504020X15942028641011. Epub 2020 Jul 8.

引用本文的文献

1
Vaccinia Virus-A Swiss Army Knife Against Cancer.痘苗病毒——对抗癌症的瑞士军刀。
Cancers (Basel). 2025 Jul 12;17(14):2324. doi: 10.3390/cancers17142324.
2
Oncolytic Viruses as a Novel Therapeutic Approach for Colorectal Cancer: Mechanisms, Current Advances, and Future Directions.溶瘤病毒作为一种治疗结直肠癌的新型方法：作用机制、当前进展及未来方向
Cancers (Basel). 2025 May 31;17(11):1854. doi: 10.3390/cancers17111854.
3
Oncolytic vaccinia virus and cancer immunotherapy.溶瘤痘苗病毒与癌症免疫疗法。

本文引用的文献

1
A high-throughput pharmacoviral approach identifies novel oncolytic virus sensitizers.高通量药理病毒学方法鉴定新型溶瘤病毒增敏剂。
Mol Ther. 2010 Jun;18(6):1123-9. doi: 10.1038/mt.2010.67. Epub 2010 Apr 13.
2
Immunomodulatory effects of deacetylase inhibitors: therapeutic targeting of FOXP3+ regulatory T cells.脱乙酰酶抑制剂的免疫调节作用：FOXP3 + 调节性T细胞的治疗靶向
Nat Rev Drug Discov. 2009 Dec;8(12):969-81. doi: 10.1038/nrd3031. Epub 2009 Oct 26.
3
Vaccinia virus K1L and C7L inhibit antiviral activities induced by type I interferons.
Front Immunol. 2024 Jan 12;14:1324744. doi: 10.3389/fimmu.2023.1324744. eCollection 2023.
4
Histone deacetylase inhibitor boosts anticancer potential of fusogenic oncolytic vaccinia virus by enhancing cell-cell fusion.组蛋白去乙酰化酶抑制剂通过增强细胞融合增强融合溶瘤痘病毒的抗癌潜力。
Cancer Sci. 2024 Feb;115(2):600-610. doi: 10.1111/cas.16032. Epub 2023 Nov 30.
5
The fluctuations of expression profiles of critical genes in the miRNA maturation process and pro-and anti-inflammatory cytokines in the pathogenesis and progression of multiple sclerosis.关键基因在 miRNA 成熟过程中的表达谱以及在多发性硬化症发病机制和进展中的促炎和抗炎细胞因子的波动。
Mol Biol Rep. 2023 Nov;50(11):9405-9416. doi: 10.1007/s11033-023-08812-8. Epub 2023 Oct 12.
6
Epigenetic Rewiring of Metastatic Cancer to the Brain: Focus on Lung and Colon Cancers.转移性癌症向脑转移的表观遗传重编程：聚焦于肺癌和结肠癌
Cancers (Basel). 2023 Apr 4;15(7):2145. doi: 10.3390/cancers15072145.
7
The employment of vaccinia virus for colorectal cancer treatment: A review of preclinical and clinical studies.痘苗病毒在结直肠癌治疗中的应用：临床前和临床研究综述。
Hum Vaccin Immunother. 2022 Nov 30;18(6):2143698. doi: 10.1080/21645515.2022.2143698. Epub 2022 Nov 11.
8
Design Strategies and Precautions for Using Vaccinia Virus in Tumor Virotherapy.肿瘤病毒治疗中痘苗病毒的设计策略与注意事项
Vaccines (Basel). 2022 Sep 17;10(9):1552. doi: 10.3390/vaccines10091552.
9
Histone modifiers at the crossroads of oncolytic and oncogenic viruses.肿瘤溶瘤病毒和致癌病毒交汇点的组蛋白修饰物。
Mol Ther. 2022 Jun 1;30(6):2153-2162. doi: 10.1016/j.ymthe.2022.02.006. Epub 2022 Feb 8.
10
Combining Oncolytic Viruses and Small Molecule Therapeutics: Mutual Benefits.溶瘤病毒与小分子疗法的联合应用：互利共赢。
Cancers (Basel). 2021 Jul 6;13(14):3386. doi: 10.3390/cancers13143386.
痘苗病毒K1L和C7L抑制I型干扰素诱导的抗病毒活性。
J Virol. 2009 Oct;83(20):10627-36. doi: 10.1128/JVI.01260-09. Epub 2009 Aug 5.
4
Engineering oncolytic viruses to exploit tumor specific defects in innate immune signaling pathways.改造溶瘤病毒以利用先天免疫信号通路中的肿瘤特异性缺陷。
Expert Opin Biol Ther. 2009 Sep;9(9):1163-76. doi: 10.1517/14712590903170653.
5
Histone deacetylase inhibitors as anti-neoplastic agents.组蛋白去乙酰化酶抑制剂作为抗肿瘤药物。
Cancer Lett. 2009 Aug 8;280(2):192-200. doi: 10.1016/j.canlet.2009.03.013. Epub 2009 Apr 3.
6
Targeted and armed oncolytic poxviruses: a novel multi-mechanistic therapeutic class for cancer.靶向性武装溶瘤痘病毒：一种新型的癌症多机制治疗类别。
Nat Rev Cancer. 2009 Jan;9(1):64-71. doi: 10.1038/nrc2545.
7
Effect of anti-fibrinolytic therapy on experimental melanoma metastasis.抗纤维蛋白溶解疗法对实验性黑色素瘤转移的影响。
Clin Exp Metastasis. 2009;26(2):121-31. doi: 10.1007/s10585-008-9221-z. Epub 2008 Dec 12.
8
Chemical targeting of the innate antiviral response by histone deacetylase inhibitors renders refractory cancers sensitive to viral oncolysis.组蛋白去乙酰化酶抑制剂对先天性抗病毒反应的化学靶向作用使难治性癌症对病毒溶瘤敏感。
Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):14981-6. doi: 10.1073/pnas.0803988105. Epub 2008 Sep 24.
9
Histone deacetylase inhibitors augment antitumor efficacy of herpes-based oncolytic viruses.组蛋白去乙酰化酶抑制剂增强基于疱疹病毒的溶瘤病毒的抗肿瘤疗效。
Mol Ther. 2008 Sep;16(9):1546-55. doi: 10.1038/mt.2008.155. Epub 2008 Jul 22.
10
The targeted oncolytic poxvirus JX-594 demonstrates antitumoral, antivascular, and anti-HBV activities in patients with hepatocellular carcinoma.靶向溶瘤痘病毒JX-594在肝细胞癌患者中表现出抗肿瘤、抗血管生成和抗乙肝病毒活性。
Mol Ther. 2008 Sep;16(9):1637-42. doi: 10.1038/mt.2008.143. Epub 2008 Jul 15.