头颈部皮肤鳞状细胞癌淋巴结转移患者的手术治疗结果。

Outcome of patients treated surgically for lymph node metastases from cutaneous squamous cell carcinoma of the head and neck.

机构信息

Department of Surgery-Head and Neck Service, Memorial-Sloan Kettering Cancer Center, New York, New York, USA.

出版信息

Head Neck. 2011 Jul;33(7):999-1004. doi: 10.1002/hed.21574. Epub 2011 Jan 31.

DOI:10.1002/hed.21574

PMID:21284049

Abstract

BACKGROUND

There is a paucity of outcomes data for patients with lymph node metastasis from cutaneous squamous cell carcinoma of head and neck (SCCHN).

METHODS

Patients from a tertiary care center with cutaneous SCCHN metastatic to parotid and or cervical lymph nodes were identified. Data were abstracted and analyzed using COX multivariate analysis.

RESULTS

Fifty-one patients (47 men, and 4 women) with a median age of 73 years were identified. Eight patients (16%) had recurrent disease and 11 (22%) were immunosuppressed. Forty patients (71%) received adjuvant radiation therapy. Median overall survival was 23 months (range, 3-148 months). Recurrent disease was associated with higher risk of death (hazard ratio [HR], 2.7; 95% confidence interval [CI] 1.1-6.9) and radiation therapy with reduced risk (HR, 0.18; 95% CI, 0.06-0.54).

CONCLUSION

Lymph node metastases from cutaneous SCCHN is associated with poor survival.

摘要

背景

头颈部皮肤鳞状细胞癌（SCCHN）淋巴结转移患者的预后数据有限。

方法

从一家三级护理中心确定了患有皮肤 SCCHN 并转移至腮腺和/或颈部淋巴结的患者。使用 COX 多变量分析对数据进行了提取和分析。

结果

共确定了 51 名患者（47 名男性和 4 名女性），中位年龄为 73 岁。8 名患者（16%）患有复发性疾病，11 名患者（22%）患有免疫抑制。40 名患者（71%）接受了辅助放疗。中位总生存期为 23 个月（范围为 3-148 个月）。复发性疾病与更高的死亡风险相关（风险比[HR]，2.7；95%置信区间[CI]，1.1-6.9），而放疗则降低了风险（HR，0.18；95% CI，0.06-0.54）。