Department of Pathology and Laboratory Medicine, University of Calgary and Calgary Laboratory Services, Alberta, Canada.
Arch Pathol Lab Med. 2011 Feb;135(2):200-6. doi: 10.5858/135.2.200.
Surgical pathology is unavailable in most of sub-Saharan Africa because of equipment costs and lack of expertise. Cytopathology is an inexpensive and reliable alternative.
To explore the utility of cytopathology in a rural hospital setting in Africa.
A cytopathologist and a pathology resident from Calgary, Alberta, Canada, went to Cameroon to provide a cytopathology service at the Banso Baptist Hospital. Both performed the fine-needle aspiration procedures. Direct smears were fixed in alcohol and stained with hematoxylin-eosin. Surgical specimens subsequently obtained from the patients were processed and reported at Calgary Laboratory Services, Canada. The histopathologic diagnoses were the gold standard for determining the accuracy of the cytologic diagnoses.
Fifty-nine patients were examined during a 5-week period, 33 females (56%) and 26 males (44%). Sixteen (27%) were known to be HIV positive. Forty-four fine-needle aspiration procedures were performed for 43 patients (73%). The cost of each procedure was approximately US $10. Head and neck and breast were the sites most frequently sampled for aspirates. Cervical smears from 5 patients were also assessed, as were 8 fluid specimens and 2 touch preparations of prostatic core biopsies. The most frequent diagnoses for malignancy were carcinoma and lymphoma. Tuberculous lymphadenitis was diagnosed in 6 patients, 4 of whom were HIV positive. Surgical specimens were received from 18 patients (30%). Cytohistologic and clinicopathologic correlation revealed 1 false-positive (1.6%) and 1 false-negative (1.6%) diagnosis.
Cytopathology is a reliable alternative for tissue diagnosis in low-resource settings.
由于设备成本和专业知识的缺乏，撒哈拉以南非洲的大多数地区都无法进行外科病理学检查。细胞病理学是一种廉价且可靠的替代方法。
探索细胞病理学在非洲农村医院环境中的应用。
来自加拿大艾伯塔省卡尔加里的一名细胞病理学家和一名病理住院医师前往喀麦隆，在班索浸信会医院提供细胞病理学服务。两人均进行了细针穿刺抽吸术。直接涂片用酒精固定，并用苏木精-伊红染色。随后从患者身上获得的手术标本在加拿大卡尔加里实验室服务公司进行处理和报告。组织病理学诊断是确定细胞学诊断准确性的金标准。
在 5 周的时间里，对 59 名患者进行了检查，其中女性 33 名（56%），男性 26 名（44%）。16 名（27%）已知 HIV 阳性。对 43 名患者中的 44 名进行了 44 次细针穿刺抽吸术。每次手术的费用约为 10 美元。头颈部和乳房是最常进行抽吸取样的部位。还评估了 5 名患者的宫颈涂片，以及 8 份液体标本和 2 份前列腺核心活检的触诊准备。最常见的恶性肿瘤诊断是癌和淋巴瘤。诊断出 6 例结核性淋巴结炎，其中 4 例 HIV 阳性。从 18 名患者（30%）中收到了手术标本。细胞组织学和临床病理学相关性显示有 1 例假阳性（1.6%）和 1 例假阴性（1.6%）诊断。
细胞病理学是资源匮乏环境中组织诊断的可靠替代方法。
