Department of Pediatric Sciences, Università Cattolica Sacro Cuore, Rome, Italy.
Ann Med. 2011 Aug;43(5):341-6. doi: 10.3109/07853890.2010.547212. Epub 2011 Feb 1.
Abstract A host of clinical scenarios can be depicted in hereditary autoinflammatory diseases, and the cardiovascular system can also be involved especially in familial Mediterranean fever (FMF), caused by mutations in the MEFV gene, and tumour necrosis factor receptor-associated periodic syndrome (TRAPS), caused by mutations in the TNFRSF1A gene. Pericardial diseases are the most represented cardiovascular abnormalities, though the role of MEFV and TNFRSF1A in the initiation of heart involvement has not been demonstrated formally and will be discussed herein.
摘要遗传性自体炎症性疾病可表现出多种临床情况，心血管系统也可受累，特别是在由 MEFV 基因突变引起的家族性地中海热 (FMF) 和由 TNFRSF1A 基因突变引起的肿瘤坏死因子受体相关周期性综合征 (TRAPS) 中。心包疾病是最常见的心血管异常，但 MEFV 和 TNFRSF1A 在心脏受累的发生中的作用尚未得到正式证实，本文将对此进行讨论。
