二氢黄曲霉毒素对大鼠肝脏线粒体的作用。1. 黄曲霉毒素B2和G2的膜依赖性渗透和氧化还原效应。
Action of dihydroaflatoxins on rat liver mitochondria. 1. Membrane-dependent osmotic and redox effects of aflatoxins B2 and G2.
作者信息
Obidoa O, Bababunmi E A, Bassir O
出版信息
Toxicology. 1978 Sep;11(1):29-36. doi: 10.1016/s0300-483x(78)90289-5.
Membrane-dependent osmotic and redox effects of two dihydroaflatoxins (aflatoxin B2 and G2) on isolated rat liver mitochondria were investigated. These toxins did not cause any marked swelling, inhibit any ATP induced contraction or stimulate ATPase activity of mitochondria at concentrations within the range 1--2 x 10(-6) M. Redox measurements on the respiratory chain showed that both toxins inhibited respiration between cytochrome c and the terminal oxygen. The significance of these findings in relation to the differential toxicity of the aflatoxins is discussed.
研究了两种二氢黄曲霉毒素（黄曲霉毒素B2和G2）对离体大鼠肝线粒体的膜依赖性渗透和氧化还原作用。在1--2×10（-6）M范围内的浓度下，这些毒素不会引起任何明显的肿胀，不会抑制任何ATP诱导的收缩，也不会刺激线粒体的ATP酶活性。对呼吸链的氧化还原测量表明，两种毒素均抑制细胞色素c与末端氧之间的呼吸作用。讨论了这些发现与黄曲霉毒素差异毒性的关系。
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