HIV 感染的非人类灵长类动物模型中的辅助受体使用。
Coreceptor use in nonhuman primate models of HIV infection.
机构信息
Aaron Diamond AIDS Research Center, 455 First Ave, 7th Floor, New York, New York, USA.
出版信息
J Transl Med. 2011 Jan 27;9 Suppl 1(Suppl 1):S7. doi: 10.1186/1479-5876-9-S1-S7.
Abstract
SIV or SHIV infection of nonhuman primates (NHP) has been used to investigate the impact of coreceptor usage on the composition and dynamics of the CD4+ T cell compartment, mechanisms of disease induction and development of clinical syndrome. As the entire course of infection can be followed, with frequent access to tissue compartments, infection of rhesus macaques with CCR5-tropic SHIVs further allows for study of HIV-1 coreceptor switch after intravenous and mucosal inoculation, with longitudinal and systemic analysis to determine the timing, anatomical sites and cause for the change in envelope glycoprotein and coreceptor preference. Here, we review our current understanding of coreceptor use in NHPs and their impact on the pathobiological characteristics of the infection, and discuss recent advances in NHP studies to uncover the underlying selective pressures for the change in coreceptor preference in vivo.
摘要
SIV 或 SHIV 感染非人类灵长类动物（NHP）已被用于研究核心受体的使用对 CD4+T 细胞区室的组成和动态、疾病诱导机制和临床综合征发展的影响。由于可以全程跟踪整个感染过程，并频繁进入组织隔室，因此用 CCR5 嗜性 SHIV 感染恒河猴还可以研究静脉内和黏膜接种后的 HIV-1 核心受体转换，进行纵向和系统性分析，以确定包膜糖蛋白和核心受体偏好改变的时间、解剖部位和原因。在这里，我们回顾了我们对 NHP 中核心受体使用及其对感染的病理生物学特征的影响的现有认识，并讨论了 NHP 研究的最新进展，以揭示体内核心受体偏好改变的潜在选择压力。
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