基于单核苷酸多态性对杜兰国家灵长类动物研究中心的普通和无特定病原体恒河猴（猕猴）种群进行基因特征分析。
SNP-based genetic characterization of the Tulane National Primate Research Center's conventional and specific pathogen-free rhesus macaque (Macaca mulatta) populations.
作者信息
Kanthaswamy Sree, Ng Jillian, Oldt Robert F, Phillippi-Falkenstein Kathrine, Kubisch H Michael
机构信息
School of Mathematics and Natural Sciences, Arizona State University (ASU) at the West Campus, Glendale, AZ, USA.
Julie Ann Wrigley Global Institute of Sustainability, Arizona State University, Tempe, AZ, USA.
出版信息
J Med Primatol. 2018 Feb;47(1):29-34. doi: 10.1111/jmp.12284. Epub 2017 Jun 21.
BACKGROUND
The rhesus macaque is an important biomedical model organism, and the Tulane National Primate Research Center (TNPRC) has one of the largest rhesus macaque breeding colonies in the United States.
METHODS
SNP profiles from 3266 rhesus macaques were used to examine the TNPRC colony genetic composition over time and across conventional or SPF animals of Chinese and Indian ancestry.
RESULTS
Chinese origin animals were the least genetically diverse and the most inbred; however, since their derivation from their conventional forebearers, neither the Chinese nor the Indian SPF animals exhibit any significant loss of genetic diversity or differentiation.
CONCLUSIONS
The TNPRC colony managers have successfully minimized loss in genetic variation across generations. Although founder effects and bottlenecks among the Indian animals have been successfully curtailed, the Chinese subpopulation still show some influences from these events.
背景
恒河猴是一种重要的生物医学模式生物，杜兰国家灵长类动物研究中心（TNPRC）拥有美国最大的恒河猴繁殖群体之一。
方法
利用3266只恒河猴的单核苷酸多态性（SNP）图谱，研究TNPRC群体随时间推移以及在中国和印度血统的传统或无特定病原体（SPF）动物中的遗传组成。
结果
中国起源的动物遗传多样性最低且近亲繁殖程度最高；然而，自它们从传统祖先衍生而来后，中国和印度的SPF动物均未表现出任何显著的遗传多样性丧失或分化。
结论
TNPRC群体管理者已成功将各代间的遗传变异损失降至最低。尽管印度动物中的奠基者效应和瓶颈效应已成功减少，但中国亚群仍显示出这些事件的一些影响。
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