Department of Internal Medicine, Clinical Immunology Unit, Stavanger University Hospital, Stavanger, Norway.
Rheumatology (Oxford). 2011 Jun;50(6):1009-18. doi: 10.1093/rheumatology/keq454. Epub 2011 Feb 1.
Chronic fatigue is a common, poorly understood and disabling phenomenon in many diseases. We aim to provide an overview of fatigue in chronic autoimmune and inflammatory disease. Fatigue measurement, prevalence and confounding factors such as depression, sleep disorders and pain are reviewed in the first half of the article. In the second half of the article, we describe explanatory models of fatigue and fatigue signalling, with an emphasis on cytokines and sickness behaviour, oxidative stress, mitochondrial dysfunction and the impact of certain genes on fatigue.
慢性疲劳是许多疾病中常见的、尚未被充分理解且使人丧失能力的现象。我们旨在提供慢性自身免疫性和炎症性疾病中疲劳的概述。本文的前半部分回顾了疲劳的测量、患病率和混杂因素，如抑郁、睡眠障碍和疼痛。在文章的后半部分，我们描述了疲劳的解释模型和疲劳信号转导，重点是细胞因子和疾病行为、氧化应激、线粒体功能障碍以及某些基因对疲劳的影响。
