Ouyang Xiaoli, Shen Qinxue, Zhou Shiting, Zhou Pei, Song Min, Guo Ting, Guo Wei, Zhang Yi, Peng Hong
Department of Pulmonary and Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Research Unit of Respiratory Disease, Central South University, Changsha, Hunan, China.
Ann Med. 2024 Dec;56(1):2398729. doi: 10.1080/07853890.2024.2398729. Epub 2024 Dec 3.
Fatigue and excessive daytime sleepiness (EDS) frequently affect interstitial lung disease (ILD) patients, while studies are limited. The study aims to determine the prevalence and contributing factors of fatigue and EDS in ILD patients.
This was a cross-sectional study. Consecutive patients diagnosed with ILD at the Second Xiangya Hospital of Central South University were recruited, and healthy volunteers were recruited as controls. Fatigue Assessment Scale and Epworth Sleepiness Scale scores were the basis for judging fatigue and EDS. The prevalence of fatigue and EDS between ILD patients and healthy volunteers were compared, and the differences in clinical characteristics between ILD patients with and without fatigue/EDS were analyzed. Binary logistic regression was used to analyze the correlation factors of fatigue and EDS.
In this study, 92 healthy volunteers and 108 ILD patients were recruited. The prevalence of fatigue and EDS was higher in ILD patients than in healthy volunteers (40.7% vs 9.8%, 35.2% vs 14.1%). ILD patients with fatigue showed significantly worse pulmonary diffusion function and exercise tolerance, alongside reduced quality of life, and increased instances of EDS, anxiety, and depression. Patients with EDS were older than non-EDS patients (68.5 vs 61.5 years; = 0.038) and had a higher prevalence of fatigue and depression, along with decreased quality of life. Multivariable logistic regression identified chest pain/oppression and diminished exercise capacity as factors linked to fatigue, and age over 60 years and diminished exercise capacity as factors associated with EDS.
ILD patients experience a higher prevalence and more severe impact of fatigue and EDS than healthy individuals, with associated factors including chest pain, diminished exercise capacity, and age. Pulmonary rehabilitation and evaluation and intervention of factors associated with fatigue and EDS such as pain, and diminished exercise capacity in ILD patients may help to improve the quality of life.
疲劳和日间过度嗜睡（EDS）经常影响间质性肺疾病（ILD）患者，但相关研究有限。本研究旨在确定ILD患者中疲劳和EDS的患病率及相关因素。
这是一项横断面研究。招募了在中南大学湘雅二医院连续诊断为ILD的患者，并招募健康志愿者作为对照。疲劳评估量表和爱泼华嗜睡量表评分是判断疲劳和EDS的依据。比较了ILD患者和健康志愿者之间疲劳和EDS的患病率，并分析了有或无疲劳/EDS的ILD患者临床特征的差异。采用二元逻辑回归分析疲劳和EDS的相关因素。
本研究共招募了92名健康志愿者和108名ILD患者。ILD患者中疲劳和EDS的患病率高于健康志愿者（40.7%对9.8%，35.2%对14.1%）。有疲劳的ILD患者肺弥散功能和运动耐力明显更差，生活质量降低，EDS、焦虑和抑郁的发生率增加。有EDS的患者比无EDS的患者年龄更大（68.5岁对61.5岁；P = 0.038），疲劳和抑郁的患病率更高，生活质量下降。多变量逻辑回归确定胸痛/胸闷和运动能力下降是与疲劳相关的因素，60岁以上年龄和运动能力下降是与EDS相关的因素。
与健康个体相比，ILD患者疲劳和EDS的患病率更高，影响更严重，相关因素包括胸痛、运动能力下降和年龄。对ILD患者进行肺康复以及评估和干预与疲劳和EDS相关的因素，如疼痛和运动能力下降，可能有助于提高生活质量。
