Technische Universität Dresden, Centre for Radiation Research in Oncology-Oncoray, Dresden, Germany.
Phys Med Biol. 2011 Mar 7;56(5):1281-98. doi: 10.1088/0031-9155/56/5/004. Epub 2011 Feb 1.
An independent assessment of the dose delivery in ion therapy can be performed using positron emission tomography (PET). For that a distribution of positron emitters which appear as the result of interaction between ions of the therapeutic beam and the irradiated tissue is measured during or after the irradiation. Three concepts for PET monitoring implemented in various therapy facilities are considered in this paper. The in-beam PET concept relies on the PET measurement performed simultaneously to the irradiation by means of a PET scanner which is completely integrated into the irradiation site. The in-room PET concept allows measurement immediately after irradiation by a standalone PET scanner which is installed very close to the irradiation site. In the off-line PET scenario the measurement is performed by means of a standalone PET/CT scanner 10-30 min after the irradiation. These three concepts were evaluated according to image quality criteria, integration costs, and their influence onto the workflow of radiotherapy. In-beam PET showed the best performance. However, the integration costs were estimated as very high for this modality. Moreover, the performance of in-beam PET depends heavily on type and duty cycle of the accelerator. The in-room PET is proposed for planned therapy facilities as a good compromise between the quality of measured data and integration efforts. For facilities which are close to the nuclear medicine departments off-line PET can be suggested under several circumstances.
可以使用正电子发射断层扫描（PET）对离子治疗中的剂量分布进行独立评估。为此，在辐照过程中或之后测量治疗束离子与辐照组织相互作用产生的正电子放射性核素的分布。本文考虑了在各种治疗设备中实现的三种用于 PET 监测的概念。在线束 PET 概念中，通过完全集成到辐照部位的 PET 扫描仪，在辐照的同时进行 PET 测量。在室内 PET 概念中，通过安装在辐照部位附近的独立 PET 扫描仪，在辐照后立即进行测量。在离线 PET 方案中，通过独立的 PET/CT 扫描仪在辐照后 10-30 分钟进行测量。根据图像质量标准、集成成本以及它们对放射治疗工作流程的影响，对这三个概念进行了评估。在线束 PET 中显示出最佳性能。然而，这种模式的集成成本估计非常高。此外，在线束 PET 的性能在很大程度上取决于加速器的类型和工作周期。对于计划治疗设备，室内 PET 是测量数据质量和集成工作之间的良好折衷方案。在几种情况下，对于靠近核医学部门的设备，可以建议在离线时使用 PET。
