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Expression of TNFRSF25 on conventional T cells and Tregs.

作者信息

Taraban Vadim Y, Ferdinand John R, Al-Shamkhani Aymen

出版信息

J Clin Invest. 2011 Feb;121(2):463-4; author reply 465. doi: 10.1172/JCI45832. Epub 2011 Feb 1.

Abstract
摘要

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The TNF-family cytokine TL1A drives IL-13-dependent small intestinal inflammation.
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Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation.
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TL1A-DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease.
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Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells.
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