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T cell regulation mediated by interaction of soluble CD52 with the inhibitory receptor Siglec-10.
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Regulation unmasked by activation.
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Siglec-10 expression is up-regulated in activated human CD4 T cells.
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Imatinib inhibits T-cell receptor-mediated T-cell proliferation and activation in a dose-dependent manner.
Blood. 2005 Mar 15;105(6):2473-9. doi: 10.1182/blood-2004-07-2527. Epub 2004 Nov 30.
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CD52 glycan binds the proinflammatory B box of HMGB1 to engage the Siglec-10 receptor and suppress human T cell function.
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CD52 is a novel costimulatory molecule for induction of CD4+ regulatory T cells.
Clin Immunol. 2006 Sep;120(3):247-59. doi: 10.1016/j.clim.2006.05.006. Epub 2006 Jun 22.

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Glycosylation in the tumor immune response: the bitter side of sweetness.
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Xist ribonucleoproteins promote female sex-biased autoimmunity.
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The meningeal transcriptional response to traumatic brain injury and aging.
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Anti-CD52 Therapy for Multiple Sclerosis: An Update in the COVID Era.
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A signature of estimate-stromal-immune score-based genes associated with the prognosis of lung adenocarcinoma.
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本文引用的文献

1
T cell regulation mediated by interaction of soluble CD52 with the inhibitory receptor Siglec-10.
Nat Immunol. 2013 Jul;14(7):741-8. doi: 10.1038/ni.2610. Epub 2013 May 19.
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Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells.
Nat Med. 2013 Jun;19(6):739-46. doi: 10.1038/nm.3179. Epub 2013 Apr 28.
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Development and maintenance of regulatory T cells.
Immunity. 2013 Mar 21;38(3):414-23. doi: 10.1016/j.immuni.2013.03.002.
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Multiple sclerosis: reprogramming the immune repertoire with alemtuzumab in MS.
Nat Rev Neurol. 2013 Mar;9(3):125-6. doi: 10.1038/nrneurol.2013.2. Epub 2013 Jan 29.
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Alemtuzumab for multiple sclerosis: a new age of immunotherapy.
J Neurol. 2013 Jan;260(1):343-5. doi: 10.1007/s00415-012-6786-x.
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Secondary autoimmune diseases following alemtuzumab therapy for multiple sclerosis.
Expert Rev Neurother. 2012 Mar;12(3):335-41. doi: 10.1586/ern.12.5.
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Siglecs and immune regulation.
Annu Rev Immunol. 2012;30:357-92. doi: 10.1146/annurev-immunol-020711-075018. Epub 2012 Jan 3.
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Autoimmune disease after alemtuzumab treatment for multiple sclerosis in a multicenter cohort.
Neurology. 2011 Aug 9;77(6):573-9. doi: 10.1212/WNL.0b013e318228bec5. Epub 2011 Jul 27.
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Expression of TNFRSF25 on conventional T cells and Tregs.
J Clin Invest. 2011 Feb;121(2):463-4; author reply 465. doi: 10.1172/JCI45832. Epub 2011 Feb 1.

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