Bayer HealthCare, Berlin, Germany.
Invest Radiol. 2011 Jun;46(6):366-9. doi: 10.1097/RLI.0b013e318209ed6f.
To determine the extent to which the gadolinium-containing contrast agents, gadobutrol (Gadovist) and gadoxetate disodium (Primovist/Eovist), interfere with the colorimetric measurement of calcium concentrations in serum and plasma.
Gadobutrol and gadoxetate disodium were added in various concentrations to serum and plasma from healthy volunteers; the calcium concentration in these samples was then measured by standard colorimetry methods and atomic absorption.
At clinically relevant concentrations, neither gadobutrol nor gadoxetate disodium influenced the results of the calcium measurement in serum or plasma. Only at the highest concentrations tested (50 mM gadobutrol; 25 mM gadoxetate disodium), an effect was seen in some cases. Results were confirmed by atomic absorption spectroscopy as the reference method.
At clinically relevant concentrations, gadobutrol and gadoxetate disodium did not interfere with standard colorimetric methods for calcium determination.
确定含钆对比剂，钆布醇（加乐显）和钆塞酸二钠（普美显/优维显）在多大程度上干扰血清和血浆中钙浓度的比色测量。
将不同浓度的钆布醇和钆塞酸二钠添加到来自健康志愿者的血清和血浆中；然后通过标准比色法和原子吸收法测量这些样品中的钙浓度。
在临床相关浓度下，钆布醇和钆塞酸二钠均不影响血清或血浆中钙测量的结果。仅在测试的最高浓度（50 mM 钆布醇；25 mM 钆塞酸二钠）下，某些情况下才会出现影响。原子吸收光谱法作为参考方法确认了结果。
在临床相关浓度下，钆布醇和钆塞酸二钠不会干扰钙测定的标准比色法。
