Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Department of Clinical Biochemistry, Copenhagen University Hospital Herlev, Herlev, Denmark.
Contrast Media Mol Imaging. 2017 Apr 10;2017:1323802. doi: 10.1155/2017/1323802. eCollection 2017.
To provide a clinically relevant overview of the analytical interference by contrast agents (CA) in laboratory blood test measurements.
The effects of five CAs, gadobutrol, gadoterate meglumine, gadoxetate disodium, iodixanol, and iomeprol, were studied on the 29 most frequently performed biochemical assays. One-day-old plasma, serum, and whole blood were spiked with doses of each agent such that the gadolinium agents and the iodine agents reached concentrations of 0.5 mM and 12 mg iodine/mL, respectively. Subsequently, 12 assays were reexamined using 1/2 and 1/4 of these CA concentrations. The results were assessed statistically by a paired Student's -test.
Iodixanol produced a negative interference on the bicarbonate ( = 0.011), lactate dehydrogenase ( < 0.0001), and zinc ( = 0.0034) assays and a positive interference on the albumin ( = 0.0062), calcium ( < 0.0001), ionized calcium ( = 0.0086), iron ( < 0.0001), and potassium ( = 0.0003) assays. Iomeprol produced a negative interference on the bicarbonate ( = 0.0057) and magnesium ( = 0.0001) assays and a positive interference on the calcium ( < 0.0001) and potassium ( = 0.0012) assays. Gadoxetate disodium produced a negative interference on the iron ( < 0.0001) and zinc ( < 0.0001) assays and a positive interference on the sodium ( = 0.032) assay.
CAs cause analytical interference. Attention should be given to the above-mentioned analyte-CA combinations when assessing laboratory blood test results obtained after CA administration.
提供对比剂（CA）在实验室血液检测测量中分析干扰的临床相关概述。
研究了五种 CA（钆布醇、钆喷酸葡胺、钆贝葡胺、碘海醇和碘普罗胺）对 29 种最常进行的生化检测的影响。在一天龄的血浆、血清和全血中加入每种试剂的剂量，使镓试剂和碘试剂的浓度分别达到 0.5mM 和 12mg 碘/mL。随后，用这些 CA 浓度的 1/2 和 1/4 重新检查了 12 种检测。使用配对学生 t 检验对结果进行统计学评估。
碘海醇对碳酸氢盐（=0.011）、乳酸脱氢酶（<0.0001）和锌（=0.0034）检测产生负干扰，对白蛋白（=0.0062）、钙（<0.0001）、离子钙（=0.0086）、铁（<0.0001）和钾（=0.0003）检测产生正干扰。碘普罗胺对碳酸氢盐（=0.0057）和镁（=0.0001）检测产生负干扰，对钙（<0.0001）和钾（=0.0012）检测产生正干扰。钆贝葡胺对铁（<0.0001）和锌（<0.0001）检测产生负干扰，对钠（=0.032）检测产生正干扰。
CA 会引起分析干扰。在评估 CA 给药后获得的实验室血液检测结果时，应注意上述分析物-CA 组合。
