Normann P T, Frøysa A, Svaland M
Nycomed Imaging AS, Oslo, Norway.
Scand J Clin Lab Invest. 1995 Aug;55(5):421-6. doi: 10.3109/00365519509104981.
The interference of the non-ionic magnetic resonance contrast medium gadodiamide injection (OMNISCAN, Nycomed Imaging, Oslo, Norway) in the colorimetric determination of serum calcium has been investigated in commercial reconstituted serum, and in serum from rabbits and humans dosed with the contrast medium. Inductively coupled plasma-atomic emission spectroscopy (ICP-AES) and ion-selective electrodes were used as reference methods for analysis of serum calcium. The results showed that the colorimetric reagent kit gave an apparent decrease in serum calcium after administration of a clinical dose of gadodiamide injection, and that the extent of interference is correlated to the concentration of the contrast medium. However, serum calcium was not changed when measured by means of an ion-selective electrode or ICP-AES. It is therefore recommended that colorimetric reagent kits should not be used for determination of serum calcium in samples taken within the first 24 h after administration of gadodiamide injection.
已在市售复溶血清以及注射造影剂后的兔和人血清中，研究了非离子型磁共振造影剂钆双胺注射液（欧乃影，奈科明影像公司，挪威奥斯陆）对比色法测定血清钙的干扰情况。采用电感耦合等离子体原子发射光谱法（ICP - AES）和离子选择电极作为分析血清钙的参考方法。结果显示，给予临床剂量的钆双胺注射液后，比色试剂试剂盒测得的血清钙明显降低，且干扰程度与造影剂浓度相关。然而，通过离子选择电极或ICP - AES测量时，血清钙并无变化。因此，建议在注射钆双胺注射液后的头24小时内采集的样本中，不应使用比色试剂试剂盒测定血清钙。
