Mirpour Sahar, Khandani Amir H
Department of Radiology, Division of Nuclear Medicine, University of North Carolina, School of Medicine, Chapel Hill, North Carolina, USA.
Nucl Med Commun. 2011 Apr;32(4):260-4. doi: 10.1097/MNM.0b013e3283440dcb.
The role of rubidium-82 (Rb) in recognizing extracardiac diseases is minimally investigated. The aim of this study was to evaluate the frequency and incremental added value of extracardiac findings on Rb cardiac positron emission tomography/computed tomography (PET/CT) studies.
The study included all consecutive patients who were referred from July 2008 to June 2010 for Rb cardiac PET/CT to our institution. A blinded reader reviewed the images retrospectively to assess abnormal extracardiac PET findings.
Images of 406 patients (142 men; 264 women) with a mean age±standard deviation of 59.72±12.93 years (range: 18-91 years) were reviewed. Incidental extracardiac abnormalities were found in 67 of 406 patients (16.5%). Among them, eight patients had malignant etiologies (1.9%).
Incidental extracardiac findings were present in a significant portion of patients undergoing Rb cardiac PET/CT studies. Although most of the extracardiac findings on Rb cardiac PET/CT studies represented clinically known pathologies, these incidental findings on routine Rb cardiac PET/CT scans may have a significant clinical impact on a small number of patients, and offer the referring physician the chance to obtain additional clinically relevant information.
关于铷-82（Rb）在识别心外疾病中的作用研究极少。本研究旨在评估心外发现对Rb心肌正电子发射断层扫描/计算机断层扫描（PET/CT）研究的频率及增量附加值。
该研究纳入了2008年7月至2010年6月期间连续转诊至我院进行Rb心肌PET/CT检查的所有患者。一名不知情的阅片者对图像进行回顾性分析，以评估心外PET异常发现。
对406例患者（142例男性；264例女性）的图像进行了分析，患者平均年龄±标准差为59.72±12.93岁（范围：18 - 91岁）。406例患者中有67例（16.5%）发现了心外偶然异常。其中，8例患者存在恶性病因（1.9%）。
在接受Rb心肌PET/CT检查的患者中，有相当一部分存在心外偶然发现。虽然Rb心肌PET/CT研究中的大多数心外发现代表了临床上已知的病变，但常规Rb心肌PET/CT扫描中的这些偶然发现可能会对少数患者产生重大临床影响，并为转诊医生提供获取更多临床相关信息的机会。
