Wang Bing, Nguyen Mai, Chang Natasha C, Shore Gordon C
Department of Biochemistry, Goodman Cancer Research Center, McGill University, Montréal, Québec, Canada.
EMBO J. 2011 Feb 2;30(3):451-2. doi: 10.1038/emboj.2010.352.
A study in this issue of sheds light on how mitochondria–ER dynamics, which affect various cell functions, regulate Bax/Bak-driven apoptosis within the complex milieu of the cell. In cell death, these organelles engage in an unanticipated two-way communication, from mitochondria to ER and back again.
本期的一项研究揭示了影响多种细胞功能的线粒体 - 内质网动态变化如何在细胞复杂环境中调节由Bax/Bak驱动的细胞凋亡。在细胞死亡过程中,这些细胞器进行了一种意想不到的双向通讯,从线粒体到内质网,再返回。