Fis1、Bap31与线粒体和内质网之间的“死亡之吻”
Fis1, Bap31 and the kiss of death between mitochondria and endoplasmic reticulum.
作者信息
Wang Bing, Nguyen Mai, Chang Natasha C, Shore Gordon C
机构信息
Department of Biochemistry, Goodman Cancer Research Center, McGill University, Montréal, Québec, Canada.
出版信息
EMBO J. 2011 Feb 2;30(3):451-2. doi: 10.1038/emboj.2010.352.
Abstract
A study in this issue of sheds light on how mitochondria–ER dynamics, which affect various cell functions, regulate Bax/Bak-driven apoptosis within the complex milieu of the cell. In cell death, these organelles engage in an unanticipated two-way communication, from mitochondria to ER and back again.
摘要
本期的一项研究揭示了影响多种细胞功能的线粒体 - 内质网动态变化如何在细胞复杂环境中调节由Bax/Bak驱动的细胞凋亡。在细胞死亡过程中，这些细胞器进行了一种意想不到的双向通讯，从线粒体到内质网，再返回。
相似文献
1
Fis1, Bap31 and the kiss of death between mitochondria and endoplasmic reticulum.Fis1、Bap31与线粒体和内质网之间的“死亡之吻”
EMBO J. 2011 Feb 2;30(3):451-2. doi: 10.1038/emboj.2010.352.
2
Fis1 and Bap31 bridge the mitochondria-ER interface to establish a platform for apoptosis induction.Fis1和Bap31连接线粒体-内质网界面，以建立一个诱导细胞凋亡的平台。
EMBO J. 2011 Feb 2;30(3):556-68. doi: 10.1038/emboj.2010.346. Epub 2010 Dec 24.
3
Apoptotic cell death "Nixed" by an ER-mitochondrial necrotic pathway.内质网-线粒体坏死途径“消除”凋亡性细胞死亡。
Proc Natl Acad Sci U S A. 2010 May 18;107(20):9031-2. doi: 10.1073/pnas.1003827107. Epub 2010 May 6.
4
Endoplasmic Reticulum-Mitochondria Communication Through Ca Signaling: The Importance of Mitochondria-Associated Membranes (MAMs).通过钙信号实现的内质网-线粒体通讯：线粒体相关膜（MAMs）的重要性。
Adv Exp Med Biol. 2017;997:49-67. doi: 10.1007/978-981-10-4567-7_4.
5
Binding of FUN14 Domain Containing 1 With Inositol 1,4,5-Trisphosphate Receptor in Mitochondria-Associated Endoplasmic Reticulum Membranes Maintains Mitochondrial Dynamics and Function in Hearts in Vivo.含FUN14结构域蛋白1与线粒体相关内质网膜上的肌醇1,4,5-三磷酸受体结合维持体内心脏线粒体动力学和功能。
Circulation. 2017 Dec 5;136(23):2248-2266. doi: 10.1161/CIRCULATIONAHA.117.030235. Epub 2017 Sep 23.
6
Over Six Decades of Discovery and Characterization of the Architecture at Mitochondria-Associated Membranes (MAMs).线粒体相关膜（MAMs）结构的六十多年发现与表征
Adv Exp Med Biol. 2017;997:13-31. doi: 10.1007/978-981-10-4567-7_2.
7
Hyperglycemia-Driven Inhibition of AMP-Activated Protein Kinase α2 Induces Diabetic Cardiomyopathy by Promoting Mitochondria-Associated Endoplasmic Reticulum Membranes In Vivo.高血糖驱动的 AMP 激活的蛋白激酶 α2 抑制作用通过促进体内线粒体相关内质网膜诱导糖尿病心肌病。
Circulation. 2019 Apr 16;139(16):1913-1936. doi: 10.1161/CIRCULATIONAHA.118.033552.
8
Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol.BAP31的半胱天冬酶切割产物通过内质网钙信号诱导线粒体分裂，增强细胞色素c释放到细胞质中。
J Cell Biol. 2003 Mar 31;160(7):1115-27. doi: 10.1083/jcb.200212059.
9
The Mitochondrial PHB2/OMA1/DELE1 Pathway Cooperates with Endoplasmic Reticulum Stress to Facilitate the Response to Chemotherapeutics in Ovarian Cancer.线粒体 PHB2/OMA1/DELE1 通路与内质网应激协同作用促进卵巢癌细胞对化疗药物的反应。
Int J Mol Sci. 2022 Jan 25;23(3):1320. doi: 10.3390/ijms23031320.
10
The mitochondrial fission protein hFis1 requires the endoplasmic reticulum gateway to induce apoptosis.线粒体分裂蛋白hFis1需要通过内质网通道来诱导细胞凋亡。
Mol Biol Cell. 2006 Nov;17(11):4593-605. doi: 10.1091/mbc.e06-05-0377. Epub 2006 Aug 16.
引用本文的文献
1
Crystal structure of Fis1 and Bap31 provides information on protein-protein interactions at mitochondria-associated ER membranes.Fis1和Bap31的晶体结构提供了关于线粒体相关内质网膜上蛋白质-蛋白质相互作用的信息。
Commun Biol. 2025 Aug 6;8(1):1161. doi: 10.1038/s42003-025-08625-4.
2
Mitochondria-associated endoplasmic reticulum membranes and myocardial ischemia: from molecular mechanisms to therapeutic strategies.线粒体相关内质网膜与心肌缺血：从分子机制到治疗策略
J Transl Med. 2025 Mar 6;23(1):277. doi: 10.1186/s12967-025-06262-3.
3
Calcium bridges built by mitochondria-associated endoplasmic reticulum membranes: potential targets for neural repair in neurological diseases.由线粒体相关内质网膜构建的钙桥：神经疾病神经修复的潜在靶点。
Neural Regen Res. 2025 Dec 1;20(12):3349-3369. doi: 10.4103/NRR.NRR-D-24-00630. Epub 2024 Nov 13.
4
Mitochondrial Dynamics in Non-Small Cell Lung Cancer.非小细胞肺癌中的线粒体动力学
Cancers (Basel). 2024 Aug 12;16(16):2823. doi: 10.3390/cancers16162823.
5
MAMs and Mitochondrial Quality Control: Overview and Their Role in Alzheimer's Disease.MAMs 与线粒体质量控制：概述及其在阿尔茨海默病中的作用。
Neurochem Res. 2024 Oct;49(10):2682-2698. doi: 10.1007/s11064-024-04205-w. Epub 2024 Jul 13.
6
A-Syn(ful) MAM: A Fresh Perspective on a Converging Domain in Parkinson's Disease.α-突触核蛋白（过度）聚集型神经突黏液样小体：帕金森病领域融合研究的新视角。
Int J Mol Sci. 2024 Jun 13;25(12):6525. doi: 10.3390/ijms25126525.
7
p20BAP31 Induces Autophagy in Colorectal Cancer Cells by Promoting PERK-Mediated ER Stress.p20BAP31 通过促进 PERK 介导的内质网应激诱导结直肠癌细胞自噬。
Int J Mol Sci. 2024 May 7;25(10):5101. doi: 10.3390/ijms25105101.
8
Metal organic layers enabled cell surface engineering coupling biomembrane fusion for dynamic membrane proteome profiling.金属有机层实现了细胞表面工程与生物膜融合的耦合，用于动态膜蛋白质组分析。
Chem Sci. 2023 Oct 5;14(42):11727-11736. doi: 10.1039/d3sc03725h. eCollection 2023 Nov 1.
9
The role of Mitochondrial Fission Proteins in Mitochondrial Dynamics in Kidney Disease.线粒体分裂蛋白在肾脏疾病中线粒体动态中的作用。
Int J Mol Sci. 2022 Nov 25;23(23):14725. doi: 10.3390/ijms232314725.
10
Cangfudaotan decoction inhibits mitochondria-dependent apoptosis of granulosa cells in rats with polycystic ovarian syndrome.苍附导痰汤抑制多囊卵巢综合征大鼠颗粒细胞线粒体依赖性细胞凋亡。
Front Endocrinol (Lausanne). 2022 Nov 9;13:962154. doi: 10.3389/fendo.2022.962154. eCollection 2022.
本文引用的文献
1
Fis1 and Bap31 bridge the mitochondria-ER interface to establish a platform for apoptosis induction.Fis1和Bap31连接线粒体-内质网界面，以建立一个诱导细胞凋亡的平台。
EMBO J. 2011 Feb 2;30(3):556-68. doi: 10.1038/emboj.2010.346. Epub 2010 Dec 24.
2
An intimate liaison: spatial organization of the endoplasmic reticulum-mitochondria relationship.亲密联系：内质网-线粒体关系的空间组织。
EMBO J. 2010 Aug 18;29(16):2715-23. doi: 10.1038/emboj.2010.177.
3
Ca(2+) transfer from the ER to mitochondria: when, how and why.钙离子从内质网向线粒体的转移：时间、方式及原因
Biochim Biophys Acta. 2009 Nov;1787(11):1342-51. doi: 10.1016/j.bbabio.2009.03.015. Epub 2009 Mar 31.
4
Mitochondrial dynamics and apoptosis.线粒体动力学与细胞凋亡。
Genes Dev. 2008 Jun 15;22(12):1577-90. doi: 10.1101/gad.1658508.
5
BAP31 interacts with Sec61 translocons and promotes retrotranslocation of CFTRDeltaF508 via the derlin-1 complex.BAP31与Sec61转运体相互作用，并通过derlin-1复合体促进CFTRDeltaF508的逆向转运。
Cell. 2008 Jun 13;133(6):1080-92. doi: 10.1016/j.cell.2008.04.042.
6
The mitochondrial fission protein hFis1 requires the endoplasmic reticulum gateway to induce apoptosis.线粒体分裂蛋白hFis1需要通过内质网通道来诱导细胞凋亡。
Mol Biol Cell. 2006 Nov;17(11):4593-605. doi: 10.1091/mbc.e06-05-0377. Epub 2006 Aug 16.
7
Endoplasmic reticulum BIK initiates DRP1-regulated remodelling of mitochondrial cristae during apoptosis.内质网BIK在细胞凋亡过程中启动DRP1调控的线粒体嵴重塑。
EMBO J. 2005 Apr 20;24(8):1546-56. doi: 10.1038/sj.emboj.7600592. Epub 2005 Mar 24.
8
Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol.BAP31的半胱天冬酶切割产物通过内质网钙信号诱导线粒体分裂，增强细胞色素c释放到细胞质中。
J Cell Biol. 2003 Mar 31;160(7):1115-27. doi: 10.1083/jcb.200212059.
9
The procaspase-8 isoform, procaspase-8L, recruited to the BAP31 complex at the endoplasmic reticulum.前半胱天冬酶-8亚型，即前半胱天冬酶-8L，在内质网处被招募至BAP31复合体。
Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4331-6. doi: 10.1073/pnas.072088099. Epub 2002 Mar 26.
10
Caspase-resistant BAP31 inhibits fas-mediated apoptotic membrane fragmentation and release of cytochrome c from mitochondria.抗半胱天冬酶的BAP31抑制Fas介导的凋亡膜片段化及细胞色素c从线粒体的释放。
Mol Cell Biol. 2000 Sep;20(18):6731-40. doi: 10.1128/MCB.20.18.6731-6740.2000.
Zotero 插件