Can Fam Physician. 1982 Mar;28:487-91.
The prognosis of Hodgkin's disease (HD) has improved impressively in the past decade. Presently, no stage of disease is beyond cure or expectancy of a long disease-free survival. The extent of disease involvement governs the choice of therapy. The treatment of choice for localized disease is irradiation, although the techniques used vary considerably among different centres. Combination chemotherapy is recommended for stages 3B and 4. The management of stage 3A and some high-risk subsets of HD remains controversial. In specific situations, combined treatments are indicated. Therapy associated complications, immediate or delayed, deserve greater attention. Ironically, their impact upon the improved survivors might be morbid and devastating.
霍奇金病(HD)的预后在过去十年中得到了显著改善。目前,没有任何疾病阶段是无法治愈或无法预期长期无病生存的。疾病的严重程度决定了治疗的选择。局限性疾病的治疗选择是放疗,尽管不同中心使用的技术差异很大。3B 和 4 期推荐使用联合化疗。3A 期和某些高危 HD 亚组的治疗管理仍存在争议。在特定情况下,需要联合治疗。治疗相关的并发症,无论是立即发生还是延迟发生,都值得更多关注。具有讽刺意味的是,这些并发症对改善的幸存者可能产生病态和毁灭性的影响。