Prosnitz L R, Farber L R, Fischer J J, Bertino J R, Fischer D B
Cancer. 1976 Jun;37(6):2826-33. doi: 10.1002/1097-0142(197606)37:6<2826::aid-cncr2820370638>3.0.co;2-f.
A new treatment program for advanced Hodgkin's disease employing five-drug combination chemotherapy and low dose radiation to the sites of bulk disease (nodal or parenchymal) was designed in 1969. Eighty patients have now been treated, 60 of whom have achieved a complete remission. More significantly, only 5 of the 60 completed responders have relapsed with follow-up from 1-6 years. The cumulative survival at 5 years of patients entering complete remission is 92%. For those patients not sustaining a complete remission, it is 19% at 2 years. This program has resulted in substantially lower relapse rates than previously reported by other investigators, probably because of the administration of radiotherapy in the manner described. Hopefully, a significant number of these patients may be cured of their disease.
1969年设计了一种针对晚期霍奇金病的新治疗方案，采用五种药物联合化疗并对大块病灶部位（淋巴结或实质脏器）进行低剂量放疗。目前已有80例患者接受了治疗，其中60例实现了完全缓解。更值得注意的是，在这60例完全缓解的患者中，仅有5例在1至6年的随访期内复发。进入完全缓解状态的患者5年累积生存率为92%。对于那些未实现完全缓解的患者，2年生存率为19%。该方案导致的复发率显著低于其他研究者先前报告的水平，这可能是由于采用了上述方式进行放射治疗。有望大量此类患者能够治愈疾病。
