Can Fam Physician. 1982 Oct;28:1813-5.
Topical medications have dramatically changed the treatment of rhinitis. While systemic treatment is often more potent, topical treatment has fewer side effects. However, topical preparations also have side effects which should be considered when treating rhinitis. Topical steroids are potent anti-inflammatories but may cause nasal bleeding; sodium cromoglycate improves allergic and general inflammation but is less potent than steroids. Topical decongestants are beneficial for short-term use when there is nasal obstruction or copious discharge, but can cause damage to nasal epithelium or atrophy and dryness of the nasal mucous membrane after years of use. Anticholinergic spray is effective when watery discharge predominates, and saline is helpful when there is nasal dryness. Treatment of associated conjunctivitis is also discussed.
局部药物治疗已显著改变了鼻炎的治疗方式。虽然全身治疗通常更有效,但局部治疗的副作用更少。然而,局部制剂也有副作用,在治疗鼻炎时应加以考虑。局部类固醇是有效的抗炎药,但可能引起鼻出血;色甘酸钠可改善过敏和一般性炎症,但不如类固醇有效。局部减充血剂在有鼻阻塞或大量分泌物时短期使用有益,但长期使用可引起鼻上皮损伤或鼻黏膜萎缩和干燥。当水样分泌物占优势时,抗胆碱能喷雾剂有效,当有鼻干燥时盐水有帮助。还讨论了相关结膜炎的治疗。