帕金森病治疗的并发症。
Complications of therapy in Parkinson's disease.
出版信息
Can Fam Physician. 1983 Jan;29:87-91.
Abstract
Despite several more effective combinations, the incidence of disability and intractable complications from levodopa therapy for Parkinson's disease is unchanged. Many of these appear to be related to the development of denervation hypersensitivity as well as to drug tolerance and loss of effect. They include dyskinesia, wearing off' phenomenon, on-off' phenomenon, and various psychic changes. More current forms of therapy with bromocriptine and drug holidays are described, emphasizing methods of preventing and controlling the incapacitating complications associated with long term drug therapy. Some future therapeutic considerations are also described.
摘要
尽管有几种更有效的联合治疗方法，但左旋多巴治疗帕金森病导致的残疾和难治性并发症的发生率并没有改变。其中许多似乎与去神经超敏反应以及药物耐受性和疗效丧失有关。这些并发症包括运动障碍、“开-关”现象和各种精神变化。本文描述了更当前的溴隐亭治疗形式和药物假期，强调了预防和控制长期药物治疗相关致残性并发症的方法。还描述了一些未来的治疗考虑。
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