Koller W C, Weiner W J, Perlik S, Nausieda P A, Goetz C G, Klawans H L
Neurology. 1981 Apr;31(4):473-6. doi: 10.1212/wnl.31.4.473.
Chronic use of levodopa may be complicated by dyskinesias, on-off effect, or hallucinosis. Transient levodopa withdrawal (drug holiday) may increase motor responsiveness and decrease levodopa-induced side effects, and the improved state may persist for as long as 9 months. After 1 year, parkinsonian signs approached pre-holiday levels, and two of the patients required a second drug holiday; side effects began to reappear 9 to 12 months after the holiday. Four of six patients with psychiatric complications remained free of hallucinations for the entire year.
长期使用左旋多巴可能会出现运动障碍、开关现象或幻觉等并发症。短暂停用左旋多巴（药物假期）可能会提高运动反应性并减少左旋多巴引起的副作用，且改善状态可能持续长达9个月。1年后，帕金森病体征接近假期前水平，其中两名患者需要进行第二次药物假期；假期后9至12个月副作用开始再次出现。6名有精神并发症的患者中有4名在一整年中都没有出现幻觉。
