合成并引入一个呋喃修饰的腺苷砌块用于 DNA 链间交联。
Synthesis and incorporation of a furan-modified adenosine building block for DNA interstrand crosslinking.
机构信息
Institute for Molecules and Materials, Radboud University Nijmegen, Heyendaalseweg 135, NL-6525 AJ, Nijmegen, The Netherlands.
出版信息
Chem Commun (Camb). 2011 Mar 14;47(10):2796-8. doi: 10.1039/c0cc04667a. Epub 2011 Feb 2.
PMID:21286656
Abstract
2'-O-(3-(Furan-2-yl)propyl)adenosine was synthesized and evaluated for interstrand crosslink (ICL) formation in DNA duplexes. In situ oxidation of the furan moiety with NIS showed rapid crosslink formation to dA and dC, while dT and dG were inactive.
摘要
2'-O-(3-(呋喃-2-基)丙基)腺苷被合成并评估了其在 DNA 双链体中形成链间交联 (ICL) 的能力。用 NIS 原位氧化呋喃部分，迅速与 dA 和 dC 形成交联，而 dT 和 dG 则没有活性。
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