从DNA交联到肽标记：呋喃氧化共轭策略的多功能性
From DNA cross-linking to peptide labeling: on the versatility of the furan-oxidation-conjugation strategy.
作者信息
Deceuninck Annelies, Madder Annemieke
机构信息
Laboratory for Organic and Biomimetic Chemistry, Department of Organic Chemistry, Krijgslaan 281, S4; B-9000 Gent, Belgium.
出版信息
Chem Commun (Camb). 2009 Jan 21(3):340-2. doi: 10.1039/b817447d. Epub 2008 Dec 1.
DOI:10.1039/b817447d
PMID:19209322
Abstract
Based on the incorporation of commercially available N-Fmoc-furylalanine, a new method for peptide labeling is proposed, relying on the selective oxidative transformation of the furan moiety into a reactive aldehyde and subsequent reductive amination.
摘要
基于市售的N-Fmoc-呋喃丙氨酸的引入，提出了一种新的肽标记方法，该方法依赖于呋喃部分选择性氧化转化为活性醛以及随后的还原胺化反应。
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