National Institute of Research and Development for Optoelectronics INOE, Magurele, Ilfov, Romania.
Arch Dermatol Res. 2011 Apr;303(3):145-51. doi: 10.1007/s00403-011-1122-3. Epub 2011 Feb 1.
Bowen's disease is a neoplastic skin disease, known as squamous cell carcinoma in situ. The treatment options for Bowen's disease are: cryotherapy, curettage, surgery, topical therapy and radiotherapy. In the past recent years, photodynamic therapy was used as a new treatment method. The purpose of this paper is to summarize the results of clinical and research studies with respect to the photodynamic therapy of Bowen's disease. A search of three databases was conducted using specific keywords and explicit inclusion and exclusion criteria for the study of photosensitizers, light sources and their efficacy in photodynamic therapy of Bowen's disease. Two photosensitizers have been used mainly for photodynamic therapy of Bowen's disease therapy: δ-aminolevulinic acid and methyl aminolevulinate. These photosensitizers have been activated with both coherent (lasers) and non-coherent (lamps and LEDs) light sources. Fluence has been set in a large domain (10-240 J/cm(2)) and irradiance was 0.23-100 mW/cm(2). All these light sources have the same efficacy. The high response rates were obtained using methyl aminolevulinate and light emitting diode as light source. These results have demonstrated that photodynamic therapy using methyl aminolevulinate as photosensitizer could be considered as one of the first therapeutic options for Bowen' disease.
鲍文病是一种皮肤肿瘤性疾病，又称为原位鳞状细胞癌。鲍文病的治疗选择包括：冷冻疗法、刮除术、手术、局部治疗和放射治疗。近年来，光动力疗法已被用作一种新的治疗方法。本文旨在总结鲍文病光动力疗法的临床和研究结果。使用特定的关键词，通过三个数据库进行了搜索，并制定了明确的纳入和排除标准，以研究光动力疗法中光敏剂、光源及其疗效。两种光敏剂主要用于鲍文病的光动力疗法：δ-氨基酮戊酸和甲氨基酮戊酸。这些光敏剂已通过相干（激光）和非相干（灯和 LED）光源进行了激活。辐照度设定在一个很大的范围内（10-240 J/cm²），辐照度为 0.23-100 mW/cm²。所有这些光源都具有相同的疗效。使用甲氨基酮戊酸和发光二极管作为光源时，获得了较高的反应率。这些结果表明，使用甲氨基酮戊酸作为光敏剂的光动力疗法可以被视为鲍文病的首选治疗方法之一。
