乳头乳晕的鲍恩病：病例报告及文献综述

Bowen's Disease of the Nipple and Areola: Case Report and Literature Review.

作者信息

Zhang Guiyun, Lu Yufeng, Liu Bin, Wang Yanmei, Li Wenyi, Xu Yangchun

机构信息

Department of Dermatology, The Second Hospital of Jilin University, Changchun, 130041, People's Republic of China.

Department of Thoracic Surgery, China-Japan Union Hospital of Jilin University, Changchun, 130000, People's Republic of China.

出版信息

Clin Cosmet Investig Dermatol. 2023 Aug 9;16:2113-2118. doi: 10.2147/CCID.S419059. eCollection 2023.

DOI:10.2147/CCID.S419059

PMID:37581009

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10423580/

Abstract

INTRODUCTION

Bowen's disease (BD) commonly occurs in sites of chronic sunlight exposure such as head, neck and extremities. It rarely distributes on the nipple and areola.

CASE PRESENTATION

A 59-year-old female presented with crusted plaque on the right breast for over 1 month. Physical examination found an asymptomatic plaque (5 cm × 5 cm) with irregular shape on the right breast. Histopathological examination suggested irregularly acanthotic epidermis and atypical epidermal cells. Dermis showed inflammatory cell infiltration. Immunohistochemical staining showed negative staining for cytokeratin 7 and cytokeratin 20, and positive staining for Ki67 (60%). The mass was excised and no recurrence occurred in the follow-up. Additionally, we reviewed the literature about BD of the breast and summarized the clinical manifestations, histological features, and treatment options.

CONCLUSION

We reported a rare BD case involving nipple and areola. Wide local excision and complete nipple excision are effective for patients with BD of the nipple and areola.

摘要

引言

鲍温病（BD）常见于长期暴露于阳光下的部位，如头部、颈部和四肢。它很少分布于乳头和乳晕。

病例报告

一名59岁女性，右侧乳房出现结痂斑块1个多月。体格检查发现右侧乳房有一个无症状的斑块（5厘米×5厘米），形状不规则。组织病理学检查显示表皮棘皮不规则增生，并有非典型表皮细胞。真皮显示有炎性细胞浸润。免疫组化染色显示细胞角蛋白7和细胞角蛋白20呈阴性染色，Ki67呈阳性染色（60%）。肿块被切除，随访期间未复发。此外，我们回顾了关于乳腺鲍温病的文献，并总结了其临床表现、组织学特征和治疗选择。