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[大鼠濒死不同阶段大脑的核苷酸池]

[Nucleotide pool of the brains of rats during different stages of dying].

作者信息

Kireev M M, Konvaĭ V D

出版信息

Vopr Med Khim. 1978 Sep-Oct;24(5):629-32.

PMID:212868
Abstract

Composition of acid-extractable fraction of nucleotides was studied in brain of dying rats after acute hemorrhage. Within the first 5 min content of ATP, GTP, UTP, GDP, UDP and NAD was distinctly decreased; content of AMP, GMP, IMP, CMP, nucleosides and nitrogen bases was markedly increased. Within the following 30 min of the dying rpocess concentration of CMP and nitrogen bases was increased but content of the other substances studied was decreased as compared with the previous experimental period. Possible effect of the alterations found on reanimation of an organism is discussed.

摘要

对急性出血后濒死大鼠脑内酸可提取核苷酸组分进行了研究。在最初5分钟内,ATP、GTP、UTP、GDP、UDP和NAD的含量明显降低;AMP、GMP、IMP、CMP、核苷和碱基的含量显著增加。在濒死过程接下来的30分钟内,CMP和碱基的浓度升高,但与前一实验阶段相比,所研究的其他物质的含量降低。讨论了所发现的这些变化对机体复苏可能产生的影响。

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