Division of Public Health Sciences, Department of Surgery, Washington University in St. Louis School of Medicine, Campus Box 8100, 660 S. Euclid Avenue, St. Louis, MO 63110, USA.
Cancer Causes Control. 2011 Apr;22(4):529-40. doi: 10.1007/s10552-011-9729-4. Epub 2011 Feb 1.
The role of estrogens in breast carcinogenesis has been investigated at the level of whole body (plasma) and cell (molecular, receptors, etc.). Growing attention focused on the breast tissue being an intracrine organ, with potentially important local estrogen production in the breast. However, very little is known about the local breast tissue estrogen levels. Understanding the role of the tissue estrogens in breast carcinogenesis might open new avenues in breast cancer prevention. This systematic review summarizes published studies that measured local estrogen levels in the breast and offers suggestions for strategies to fill gaps in our existing scientific knowledge.
雌激素在乳腺癌发生中的作用已在全身（血浆）和细胞（分子、受体等）水平上进行了研究。人们越来越关注乳腺组织作为一种内分泌器官，在乳腺中可能具有重要的局部雌激素产生。然而，对于局部乳腺组织中的雌激素水平知之甚少。了解组织雌激素在乳腺癌发生中的作用可能为乳腺癌预防开辟新途径。本系统综述总结了已发表的测量乳腺局部雌激素水平的研究，并提出了一些建议，以填补我们现有科学知识中的空白。
