Department of Otorhinolaryngology, Head and Neck Surgery, Munich University, Marchioninistr. 15, 81377, Munich, Germany.
Curr Oncol Rep. 2011 Apr;13(2):126-31. doi: 10.1007/s11912-011-0156-1.
Functional outcome and quality of life have become frequent outcome measures in head and neck cancer (HNC) clinical trials. Many thoroughly validated outcome measures are available. Still, there is a low degree of standardization and comparability among measures. It seems difficult to fully translate the new insights into clinical routine. The aims of this paper are 1) to acknowledge the diversity of outcome measures and many of the past milestones that have been reached, but also 2) to capture a growing need to concentrate and reach consensus. The hypothesis is to gain more benefit from changing the perspective toward consensus rather than diversity in functional outcome assessment. The next steps are to adopt a unique "language" to describe functional outcome and implement clear end points that assist clinical decision making. The International Classification of Functioning, Disability, and Health was adopted by the WHO and offers an internationally accepted classification to describe disability in HNC.
功能结果和生活质量已成为头颈部癌症(HNC)临床试验中常用的结果衡量指标。有许多经过充分验证的结果衡量指标可用。尽管如此,这些衡量指标之间的标准化和可比性仍然较低。似乎很难将新的见解完全转化为临床常规。本文的目的是 1)承认结果衡量指标的多样性以及已经取得的许多里程碑式成就,但也 2)认识到需要集中精力并达成共识的日益增长的需求。其假设是,通过改变功能结果评估的视角,从多样性转向共识,从而获得更多的益处。下一步是采用独特的“语言”来描述功能结果,并实施明确的终点,以协助临床决策。国际功能、残疾和健康分类被世界卫生组织采用,为描述 HNC 中的残疾提供了国际公认的分类。