Inada Masaki, Matsumoto Chiho, Miyaura Chisato
Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology.
Clin Calcium. 2011 Feb;21(2):164-70.
Ovariectomized (OVX) animal is a typical experimental model for investigation of postmenopausal osteoporosis due to estrogen deficiency in women. Recently, both OVX mouse and OVX rat are commonly used for the evaluation of bone tissues in the animal model. OVX mouse is appropriate for the study of pathogenesis of postmenopausal osteoporosis, since various gene knockout mice are available for the experiments. OVX rat model is widely used for the evaluation and development of new drug compounds for postmenopausal osteoporosis treatments. On the other hand, orchidectomized (ORX) animal model is excellent in the study of osteoporosis due to androgen deficiency in men. Both OVX and ORX animal exhibits marked bone loss with increased bone resorption. We focused on the feature and evaluation technique for bone tissues in OVX and ORX animals.
卵巢切除（OVX）动物是研究女性因雌激素缺乏导致的绝经后骨质疏松症的典型实验模型。最近，OVX小鼠和OVX大鼠都常用于动物模型中骨组织的评估。OVX小鼠适用于绝经后骨质疏松症发病机制的研究，因为有各种基因敲除小鼠可用于实验。OVX大鼠模型广泛用于绝经后骨质疏松症治疗新药化合物的评估和开发。另一方面，去势（ORX）动物模型在研究男性雄激素缺乏导致的骨质疏松症方面表现出色。OVX和ORX动物均表现出明显的骨质流失，骨吸收增加。我们关注OVX和ORX动物骨组织的特征和评估技术。
