Department of Neurology, University of California, San Francisco, California 94143, USA.
Pediatr Res. 2011 May;69(5 Pt 2):48R-54R. doi: 10.1203/PDR.0b013e3182130c54.
Atypical sensory-based behaviors are a ubiquitous feature of autism spectrum disorders (ASDs). In this article, we review the neural underpinnings of sensory processing in autism by reviewing the literature on neurophysiological responses to auditory, tactile, and visual stimuli in autistic individuals. We review studies of unimodal sensory processing and multisensory integration that use a variety of neuroimaging techniques, including electroencephalography (EEG), magnetoencephalography (MEG), and functional MRI. We then explore the impact of covert and overt attention on sensory processing. With additional characterization, neurophysiologic profiles of sensory processing in ASD may serve as valuable biomarkers for diagnosis and monitoring of therapeutic interventions for autism and reveal potential strategies and target brain regions for therapeutic interventions.
非典型感觉行为是自闭症谱系障碍（ASD）的普遍特征。在本文中，我们通过回顾自闭症个体对听觉、触觉和视觉刺激的神经生理反应的文献，来综述自闭症中感觉处理的神经基础。我们综述了使用各种神经影像学技术（包括脑电图（EEG）、脑磁图（MEG）和功能磁共振成像（fMRI））的单模态感觉处理和多感觉整合的研究。然后，我们探讨了隐蔽和显性注意对感觉处理的影响。通过进一步的特征描述，ASD 感觉处理的神经生理特征可能成为自闭症诊断和治疗干预监测的有价值的生物标志物，并揭示潜在的治疗干预策略和目标脑区。
