基于微小RNA的癌症治疗：小RNA带来的巨大希望
MicroRNA-based Cancer Therapeutics: Big Hope from Small RNAs.
作者信息
Bhardwaj Arun, Singh Seema, Singh Ajay P
机构信息
Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama, USA, 36604.
出版信息
Mol Cell Pharmacol. 2010;2(5):213-219. doi: 10.4255/mcpharmacol.10.27.
Abstract
Tremendous progress has been made during the last few years in identification of novel tumor-associated microRNAs and experimental validation of their cancer relevant gene targets. Indeed, these small non-coding RNAs are now known to modulate many biological pathways related to cancer progression, metastasis and therapy-resistance. Therefore, modulating miRNA functions may provide novel therapeutic opportunities for cancer treatment. This article reviews recent literature on the role of miRNAs in cancer with an emphasis on their potential as cancer therapeutics.
摘要
在过去几年中，在鉴定新型肿瘤相关微小RNA及其癌症相关基因靶点的实验验证方面取得了巨大进展。事实上，现在已知这些小的非编码RNA可调节许多与癌症进展、转移和治疗耐药性相关的生物学途径。因此，调节miRNA功能可能为癌症治疗提供新的治疗机会。本文综述了关于miRNA在癌症中的作用的最新文献，重点是它们作为癌症治疗手段的潜力。
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