Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, UNC-Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Chem Res Toxicol. 2011 Feb 18;24(2):165-7. doi: 10.1021/tx1004419. Epub 2011 Feb 4.
Inorganic arsenic (iAs) is an environmental toxicant currently poisoning millions of people worldwide, and chronically exposed individuals are susceptible to arsenicosis or arsenic poisoning. Using a state-of-the-art technique to map the methylomes of our study subjects, we identified a large interactome of hypermethylated genes that are enriched for their involvement in arsenic-associated diseases, such as cancer, heart disease, and diabetes. Notably, we have uncovered an arsenic-induced tumor suppressorome, a complex of 17 tumor suppressors known to be silenced in human cancers. This finding represents a pivotal clue in unraveling a possible epigenetic mode of arsenic-induced disease.
无机砷（iAs）是一种环境毒物，目前正在毒害全球数百万人，长期暴露于无机砷的人易患砷中毒或砷中毒。本研究采用最先进的技术来绘制研究对象的甲基组图谱，鉴定出一组超甲基化基因的大型相互作用组，这些基因参与了与砷相关的疾病，如癌症、心脏病和糖尿病。值得注意的是，我们发现了砷诱导的肿瘤抑制因子组，这是一组已知在人类癌症中被沉默的 17 个肿瘤抑制因子。这一发现为揭示砷诱导疾病的可能表观遗传模式提供了关键线索。
