Institute for Translational Epidemiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Department of Thoracic Surgery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Biomolecules. 2024 Oct 15;14(10):1302. doi: 10.3390/biom14101302.
The collapse of the World Trade Center (WTC) buildings in New York City generated a large plume of dust and smoke. WTC dust contained human carcinogens including metals, asbestos, polycyclic aromatic hydrocarbons (PAHs), persistent organic pollutants (POPs, including polychlorinated biphenyls (PCBs) and dioxins), and benzene. Excess levels of many of these carcinogens have been detected in biological samples of WTC-exposed persons, for whom cancer risk is elevated. As confirmed in this structured literature review (n studies = 80), all carcinogens present in the settled WTC dust (metals, asbestos, benzene, PAHs, POPs) have previously been shown to be associated with DNA methylation dysregulation of key cancer-related genes and pathways. DNA methylation is, therefore, a likely molecular mechanism through which WTC exposures may influence the process of carcinogenesis.
纽约世界贸易中心大楼的倒塌产生了大量的灰尘和烟雾。世贸中心的灰尘中含有人类致癌物，包括金属、石棉、多环芳烃（PAHs）、持久性有机污染物（POPs，包括多氯联苯（PCBs）和二恶英）以及苯。在接触世贸中心尘埃的人的生物样本中检测到了许多这些致癌物的过量水平，这些人的癌症风险增加。正如本结构文献综述（n 项研究=80）所证实的那样，沉降的世贸中心尘埃中存在的所有致癌物（金属、石棉、苯、PAHs、POPs）以前都被证明与关键癌症相关基因和途径的 DNA 甲基化失调有关。因此，DNA 甲基化是一个可能的分子机制，通过该机制，世贸中心的暴露可能会影响致癌过程。
