三重威胁：心脏心律失常、缺血和心力衰竭病理生理学中的 Na+/Ca2+ 交换器。
Triple threat: the Na+/Ca2+ exchanger in the pathophysiology of cardiac arrhythmia, ischemia and heart failure.
机构信息
University Hospital of Muenster, Department of Cardiology and Angiology, Albert-Schweitzer-Str. 33, 48149 Muenster, Germany.
出版信息
Curr Drug Targets. 2011 May;12(5):737-47. doi: 10.2174/138945011795378559.
Abstract
The Na(+)/Ca(2+) exchanger (NCX) is the main Ca(2+) extrusion mechanism of the cardiac myocyte and thus is crucial for maintaining Ca(2+) homeostasis. It is involved in the regulation of several parameters of cardiac excitation contraction coupling, such as cytosolic Ca(2+) concentration, repolarization and contractility. Increased NCX activity has been identified as a mechanism promoting heart failure, cardiac ischemia and arrhythmia. Transgenic mice as well as pharmacological interventions have been used to support the idea of using NCX inhibition as a future pharmacological strategy to treat cardiovascular disease.
摘要
钠钙交换体（NCX）是心肌细胞中主要的钙离子外排机制，因此对维持钙离子稳态至关重要。它参与调节心脏兴奋-收缩偶联的几个参数，如胞浆钙离子浓度、复极化和收缩性。增加 NCX 的活性已被确定为促进心力衰竭、心脏缺血和心律失常的机制之一。转基因小鼠以及药物干预已被用于支持使用 NCX 抑制作为未来治疗心血管疾病的药理学策略的想法。
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