Hall G, Lind M J, Huang M, Moore A, Gane A, Roberts J T, Cantwell B M
University Department of Clinical Oncology, Newcastle General Hospital, Newcastle upon Tyne, UK.
Postgrad Med J. 1990 Oct;66(780):860-1. doi: 10.1136/pgmj.66.780.860.
We report three patients who had serious disturbance of anticoagulant control while receiving ifosfamide/mesna-containing cytotoxic chemotherapy in association with warfarin. In view of the likely biological potentiation of warfarin by ifosfamide/mesna, close monitoring of anticoagulant control should be performed during the co-administration of these drugs.
我们报告了三名患者，他们在接受含异环磷酰胺/美司钠的细胞毒性化疗联合华法林治疗期间，抗凝控制出现严重紊乱。鉴于异环磷酰胺/美司钠可能对华法林产生生物学增效作用，在联合使用这些药物期间应密切监测抗凝控制情况。
