Department of Medicine, Aminu Kano Teaching Hospital, Kano, Nigeria.
J Clin Lipidol. 2008 Aug;2(4):274-8. doi: 10.1016/j.jacl.2008.03.002. Epub 2008 Mar 22.
In a nationwide survey of Nigeria, residents of Kano were shown to have the highest prevalence of hypertension and the highest levels of plasma cholesterol. Because hypertension and high cholesterol together markedly increase the risk for cardiovascular disease, we examined lipid profiles among hypertensives and nonhypertensives in Kano. To determine the extent to which there were differences in lipid profiles based on therapy for blood pressure, we created three strata for comparison.
The study was conducted at Aminu Kano Teaching Hospital, Kano, Nigeria. Lipid levels were examined among randomly selected hypertensives on antihypertensive regimens (n = 70), treatment-naïve hypertensives (n = 70), and normotensive individuals (n = 70) matched for age and gender. Overall mean age for hypertensives was 50.5 ± 11.9 years, and 54.3% were female. For the control group, mean age was 49.3 ± 12.9 years, and 55.7% were female.
Mean total cholesterol of the hypertensives on therapy (group 1) was 5.69 ± 1.19 mmol/L. Total cholesterol was significantly higher than levels in the treatment-naïve hypertensives (group 2) (5.24 ± 0.76 mmol/L; P = 0.01) and the controls (group 3) (4.91 ± 0.72 mmol/L; P = 0.000). Significant differences were also evident between groups for low-density lipoprotein (LDL) cholesterol. For high-density lipoprotein (HDL) cholesterol, the difference between the hypertensives on therapy and the treatment-naïve was not significant. Difference in this index between each hypertensive group and control was significant. The difference between groups for triglycerides followed the same pattern as HDL cholesterol. Increased total cholesterol (>6.5 mmol/L) was found to be 20%, 4.4%, and 1.4% in the hypertensive on therapy, treatment-naïve hypertensive, and control groups, respectively.
High levels of total and LDL cholesterol were more prevalent in treated versus untreated hypertensives and normotensive individuals, suggesting co-occurrence of two important risk factors for cardiovascular disease that is not ameliorated by treatment for hypertension.
在一项对尼日利亚全国范围的调查中，研究人员发现卡诺居民的高血压患病率和血浆胆固醇水平最高。由于高血压和高胆固醇同时显著增加心血管疾病的风险，我们研究了卡诺的高血压患者和非高血压患者的血脂谱。为了确定基于血压治疗的血脂谱差异程度，我们创建了三个比较层。
该研究在尼日利亚卡诺教学医院进行。在接受抗高血压治疗方案的随机选择的高血压患者中（n=70）、未经治疗的高血压患者（n=70）和年龄和性别相匹配的正常血压个体中（n=70），检查血脂水平。高血压患者的总体平均年龄为 50.5±11.9 岁，54.3%为女性。对照组的平均年龄为 49.3±12.9 岁，55.7%为女性。
接受治疗的高血压患者（第 1 组）的总胆固醇平均为 5.69±1.19mmol/L。总胆固醇显著高于未经治疗的高血压患者（第 2 组）（5.24±0.76mmol/L；P=0.01）和对照组（第 3 组）（4.91±0.72mmol/L；P=0.000）。在低密度脂蛋白（LDL）胆固醇方面，各组之间也存在显著差异。对于高密度脂蛋白（HDL）胆固醇，接受治疗的高血压患者和未经治疗的高血压患者之间的差异无统计学意义。每个高血压组与对照组之间的差异在该指标上均有统计学意义。甘油三酯的差异模式与 HDL 胆固醇相同。在接受治疗的高血压患者、未经治疗的高血压患者和对照组中，总胆固醇升高（>6.5mmol/L）的比例分别为 20%、4.4%和 1.4%。
与未经治疗的高血压患者和正常血压个体相比，接受治疗的高血压患者的总胆固醇和 LDL 胆固醇水平更高，这表明心血管疾病的两个重要危险因素同时存在，而高血压治疗并不能改善这种情况。
