Fleck C, Schilder L, Schulze U, Pfister M, Stein G, Landmann H, Schwachula G, Bräunlich H
Abteilung für Pharmakologie, Bereiches Medizin der Friedrich-Schiller-Universität Jena.
Z Gesamte Inn Med. 1990 Oct 15;45(20):604-9.
Bonnecor is excreted in rats both via urine (3/4) and bile (1/4). It was the aim of this study to find out suitable methods for detoxication of a poisoning with this antiarrhytmic drug. In vivo methods intended to enhance the renal excretion of Bonnecor (forced diuresis, changes in urinary pH-values, peritoneal dialysis) are not qualified for therapeutically relevant increase of Bonnecor elimination. Relating to this Bonnecor is quite comparable with other antiarrhythmic drugs or dibenzazepine derivatives. The hemoperfusion can be recommended for the therapy of a Bonnecor overdosage as a propping up of symptomatic methods of intensive care, which are precendentally indicated. Therefore the therapy of a Bonnecor poisoning seems to be more promising compared to intoxications with other antiarrhythmics. Among the adsorbents tested, the resin Wofatit UH91 is most suitable to remove Bonnecor from the organism. If hemoperfusion equipments are not available, hemodialysis can also be used for acceleration of Bonnecor elimination, although its effectivity is only one third of that of hemoperfusion.
博纳可（Bonnecor）在大鼠体内通过尿液（3/4）和胆汁（1/4）排泄。本研究的目的是找出针对这种抗心律失常药物中毒的合适解毒方法。旨在增强博纳可肾排泄的体内方法（强制利尿、尿液pH值改变、腹膜透析）对于博纳可消除的治疗相关增加并不适用。就此而言，博纳可与其他抗心律失常药物或二苯氮䓬衍生物相当。血液灌流可作为重症监护对症方法的辅助手段，推荐用于博纳可过量中毒的治疗，这是之前所指明的。因此，与其他抗心律失常药物中毒相比，博纳可中毒的治疗似乎更有前景。在所测试的吸附剂中，Wofatit UH91树脂最适合从机体中去除博纳可。如果没有血液灌流设备，血液透析也可用于加速博纳可的消除，尽管其效果仅为血液灌流的三分之一。
