Alberta Institute for Human Nutrition, 4-10 Agriculture Forestry Centre, Edmonton, Alberta, T6G 2P5, Canada (Ms. Su, Ms. Nzekwu, and Dr. Proctor); and Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada (Drs. Ball and Jetha).
J Clin Lipidol. 2009 Apr;3(2):78-84. doi: 10.1016/j.jacl.2009.02.006. Epub 2009 Feb 11.
Abstract. The growing trend of childhood overweight and obesity is a major health concern worldwide. Although obesity is a key risk factor for cardiovascular disease, the etiologic link between obesity and the progression of vascular disease remains unknown. Traditionally, lowering fasting blood cholesterol concentration has been the main interventional target for decreasing the risk of heart disease. However, there is increasing evidence that elevated concentrations of intestinally-derived chylomicron particles are associated with cardiovascular disease risk and that this is particularly evident in insulin-resistance and obesity in adulthood. In this review we comment on recent evidence suggesting that overweight children have fasting chylomicron concentrations equivalent to that found in adults diagnosed with cardiovascular disease. Further, we consider the hypothesis that fasting and postprandial chylomicron metabolism has a central role in the genesis of cardiovascular disease during childhood obesity.
摘要。儿童超重和肥胖趋势日益严重，是全球主要的健康关注点。尽管肥胖是心血管疾病的一个关键风险因素，但肥胖与血管疾病进展之间的病因联系尚不清楚。传统上，降低空腹血胆固醇浓度一直是降低心脏病风险的主要干预目标。然而，越来越多的证据表明，肠源性乳糜微粒颗粒浓度升高与心血管疾病风险相关，在成年期胰岛素抵抗和肥胖中尤为明显。在这篇综述中，我们评论了最近的证据，表明超重儿童的空腹乳糜微粒浓度与被诊断患有心血管疾病的成年人相当。此外，我们考虑了这样一种假设，即空腹和餐后乳糜微粒代谢在儿童肥胖期间心血管疾病的发生中起核心作用。
