Instituto de la Grasa-CSIC, 41013 Seville, Spain.
Department of Molecular Biology and Biochemical Engineering, Faculty of Experimental Sciences, University of Pablo de Olavide, 41013 Seville, Spain.
Int J Mol Sci. 2024 Jan 16;25(2):1112. doi: 10.3390/ijms25021112.
In the context of the alarming rise of infant obesity and its health implications, the present research aims to uncover disruptions in postprandial lipid metabolism and the composition of triglyceride-rich lipoproteins in obese adolescents. A double-blind, controlled clinical trial in the postprandial phase on 23 adolescents aged 12 to 16 years was carried out. Twelve participants were categorized as obese (BMI > 30 kg/m and percentile > 95) and 11 as normal-weight (BMI = 20-25 kg/m, percentile 5-85). Blood samples were collected after a 12-h overnight fast and postprandially after consumption of a standardized breakfast containing olive oil, tomato, bread, orange juice, and skimmed milk. Obese adolescents exhibited elevated triglyceride concentrations in both fasting and postprandial states and higher TG/apo-B48 ratios, indicating larger postprandial triglyceride-rich lipoprotein (TRL) particle size, which suggests impaired clearance. Obese subjects also exhibited higher n-6 PUFA concentrations, potentially linked to increased TRL hydrolysis and the release of pro-inflammatory adipokines. In contrast, TRL from normal-weight individuals showed higher concentrations of oleic acid and DHA (n-3 PUFA), with possible anti-inflammatory effects. The results indicate an interplay involving postprandial TRL metabolism and adipokines within the context of adolescent obesity, pointing to potential cardiovascular implications in the future.
在婴儿肥胖及其健康影响令人担忧的上升背景下，本研究旨在揭示肥胖青少年餐后脂质代谢和富含甘油三酯脂蛋白组成的紊乱。对 23 名 12 至 16 岁的青少年进行了餐后双盲对照临床试验。12 名参与者被归类为肥胖（BMI > 30 kg/m 和百分位> 95），11 名参与者为正常体重（BMI = 20-25 kg/m，百分位 5-85）。在 12 小时夜间禁食后和摄入含有橄榄油、番茄、面包、橙汁和脱脂牛奶的标准化早餐后采集血样。肥胖青少年在空腹和餐后状态下甘油三酯浓度升高，TG/apo-B48 比值更高，表明餐后富含甘油三酯的脂蛋白 (TRL) 颗粒尺寸较大，提示清除能力受损。肥胖受试者还表现出更高的 n-6 PUFA 浓度，这可能与 TRL 水解和促炎脂肪因子的释放有关。相比之下，来自正常体重个体的 TRL 表现出更高的油酸和 DHA（n-3 PUFA）浓度，可能具有抗炎作用。结果表明，在青少年肥胖的背景下，涉及餐后 TRL 代谢和脂肪因子的相互作用，这表明未来可能存在心血管影响。
