Cellular Biochemistry & Genomics Division, Defence Institute of Physiology & Allied Sciences, Lucknow Road, Timarpur, Delhi 110054, India.
Int J Biochem Cell Biol. 2011 May;43(5):697-700. doi: 10.1016/j.biocel.2011.01.019. Epub 2011 Feb 1.
Scavenger receptors are modified lipoprotein binding receptors, expressed on the surface of a variety of cells including endothelial, macrophages and platelets. The most extensively studied class B scavenger receptors comprise of CD36 and SR-BI and have been found to bind to native and modified LDL. Interaction of modified LDL to CD36 accelerates foam cell formation, the key step in atherosclerotic plaque deposition. Recently scavenger receptors have also been implicated in thrombosis. Platelet CD36 serves as a sensor of oxidative stress and modulator of platelet reactivity under hyperlipidemic conditions thus, inducing prothrombotic signals. In contrast, targeting platelet SR-BI corresponds to reduce platelet hyperreactivity in hyperlipidemia suggesting that targeting these receptors could be a promising strategy for the treatment of atherothrombotic disorders.
清道夫受体是一种经过修饰的脂蛋白结合受体，表达于多种细胞表面，包括内皮细胞、巨噬细胞和血小板。研究最为广泛的 B 类清道夫受体包括 CD36 和 SR-BI，已被发现可结合天然和修饰的 LDL。修饰的 LDL 与 CD36 的相互作用加速了泡沫细胞的形成，这是动脉粥样硬化斑块沉积的关键步骤。最近，清道夫受体也与血栓形成有关。血小板 CD36 作为氧化应激的传感器，在高脂血症条件下调节血小板反应性，从而诱导促血栓形成信号。相反，靶向血小板 SR-BI 可减少高脂血症中的血小板高反应性，这表明靶向这些受体可能是治疗动脉粥样硬化血栓形成性疾病的一种有前途的策略。
