Department of Pediatric Surgery, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012, India.
J Pediatr Surg. 2011 Feb;46(2):e5-8. doi: 10.1016/j.jpedsurg.2010.09.103.
Neural tube closure is a complex spatio-temporal process. Multiple neural tube defects (NTDs) in a single patient are extremely rare. Only a few cases of multiple NTDs have been reported in the world literature, including less than 20 cases of double NTDs and 3 cases of triple NTDs. We report a fourth case of triple NTDs and review the literature regarding the embryogenesis. An effort is made to understand the theories of neural tube closure in light of recent advances in molecular biology and identification of the signaling pathways involved.
神经管闭合是一个复杂的时空过程。单个患者中出现多种神经管缺陷（NTD）极为罕见。全世界文献中仅报道了少数几种多发性 NTD 病例，包括少于 20 例的双发性 NTD 和 3 例的多发性 NTD。我们报告了第四例多发性 NTD，并对胚胎发生的文献进行了回顾。鉴于分子生物学的最新进展和涉及的信号通路的鉴定，我们努力理解神经管闭合的理论。
