Zwergel U E, Zwergel T B, Neisius D A, Ziegler M
Urological Clinic and Policlinic of Saarland University, Homburg/Saar, FRG.
Urol Res. 1990;18(6):429-33. doi: 10.1007/BF00297379.
Prostaglandin inhibitors such as indomethacin have been used for the treatment of renal colic. While opioids have a central analgesic effect, the effects of indomethacin are mainly peripheral, acting directly on the kidney. Pharmacourodynamic investigations of the upper urinary tract in men have demonstrated that intravenous indomethacin reduces renal pelvic pressure. These effects are more intense with indomethacin than with metamizol and are not found with hyoscine butylbromide. We have determined that indomethacin reduces the smooth muscle activity of human renal pelvis preparations in a tissue bath. These findings may represent a further possible direct effect of indomethacin on the upper urinary tract during the treatment of renal colic.
前列腺素抑制剂如吲哚美辛已被用于治疗肾绞痛。虽然阿片类药物具有中枢镇痛作用，但吲哚美辛的作用主要是外周性的，直接作用于肾脏。对男性上尿路的药效学研究表明，静脉注射吲哚美辛可降低肾盂压力。与安乃近相比，吲哚美辛的这些作用更强，而丁溴东莨菪碱则没有这些作用。我们已经确定，吲哚美辛可降低组织浴中人类肾盂制剂的平滑肌活性。这些发现可能代表了吲哚美辛在治疗肾绞痛期间对上尿路的另一种可能的直接作用。
