Gasparich J P, Mayo M E
J Urol. 1986 May;135(5):1088-90. doi: 10.1016/s0022-5347(17)45981-7.
Comparative effects of four prostaglandin synthesis inhibitors (PGSI) on the acutely obstructed kidney were studied using an intact canine model. Trigonal vesicostomies were constructed and totally implanted nephrostomy tubes were placed to monitor renal pelvic pressures. After recovery, experiments were run at weekly intervals with one drug administered each week in a random fashion. Complete ureteral obstruction was obtained using a Fogarty balloon catheter passed retrogradely into the distal ureter and inflated. When renal pelvic pressure reached 80 cm./H2O the designated PGSI was given and a repeat dose was given 30 minutes later. Mean blood pressure was also monitored during several experiments. With the first dose significant decreases in renal pelvic pressure were obtained with all drugs tested. Only ibuprofen showed a significant further decrease with the second dose. Ibuprofen showed the greatest decrease in pressure with the first dose, which was significantly greater than the other drugs tested. There was no association between mean blood pressure changes and the nadir of renal pelvic pressure.
使用完整的犬模型研究了四种前列腺素合成抑制剂（PGSI）对急性梗阻性肾脏的比较作用。构建了膀胱三角区膀胱造口术，并放置完全植入的肾造瘘管以监测肾盂压力。恢复后，每周进行一次实验，每周以随机方式给予一种药物。使用逆行插入远端输尿管并充气的Fogarty球囊导管实现完全输尿管梗阻。当肾盂压力达到80厘米水柱时，给予指定的PGSI，并在30分钟后给予重复剂量。在几次实验中还监测了平均血压。使用所有测试药物，首次给药后肾盂压力均显著降低。只有布洛芬在第二次给药后显示出进一步的显著降低。布洛芬在首次给药后压力下降最大，显著大于其他测试药物。平均血压变化与肾盂压力最低点之间没有关联。
