Barocci S, Fenoglio D, Leprini A, Nocera A
Servizio di Immunologia-Ospedale S. Martino e Università di Genova.
Boll Soc Ital Biol Sper. 1990 Dec;66(12):1193-200.
In this study, different intravenous immunoglobulin infusions (I.V. Ig.), were analyzed for the presence of either anti-HLA antibodies (Ab1) or anti-idiotypic antibodies (Ab2) directed against Ab1 anti-HLA. No evidence of either antibody types was found in tested I.V. Ig. preparations. Because of the absence of Ab1 anti-HLA, prophylactic and/or therapeutic use of I.V. Ig. appears safe in patients waiting for organ graft or in transplanted patients. The lack of Ab2 anti-Ab1 anti-HLA makes worthless the utilization of such preparations for neutralization of Ab1 present in highly sensitized dialysis patients or suppression of their production in transplanted patients in contrast with the previous reports suggesting this possibility.
在本研究中，分析了不同的静脉注射免疫球蛋白（I.V. Ig.），以检测针对抗HLA抗体（Ab1）或针对抗Ab1抗HLA的抗独特型抗体（Ab2）的存在情况。在所测试的I.V. Ig.制剂中未发现任何一种抗体的证据。由于不存在抗HLA的Ab1，I.V. Ig.在等待器官移植的患者或移植患者中进行预防性和/或治疗性使用似乎是安全的。与之前提示这种可能性的报告相反，缺乏抗Ab1抗HLA的Ab2使得利用此类制剂中和高度致敏透析患者中存在的Ab1或抑制移植患者中其产生变得毫无价值。
