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[单克隆丙种球蛋白病的神经病变。具有淀粉样结构的免疫球蛋白的免疫荧光及电子显微镜免疫标记(作者译)]

[The neuropathies of monoclonal gammapathies. Immunofluorescence and immunolabelling in the electron microscopy of immunoglobulins with amyloid structure (author's transl)].

作者信息

Carrier H, Guillaud-Barbaret C, Chazot G, Bady B, Schott B

出版信息

Acta Neuropathol. 1978 Oct 13;44(1):77-81. doi: 10.1007/BF00691643.

Abstract

Five cases of peripheral neuropathies occurring with monoclonal gammapathies are studied by means of nerve biopsies. Immunofluorescence and HRP-immunolabelling with the electron microscope are performed. The direct pathogenic role of a subperineurial immunoglobulin deposit is pointed out. The relationship of the heavy chain monoclonal immunoglobulin with amyloid fibrils is discussed.

摘要

通过神经活检对5例伴有单克隆丙种球蛋白病的周围神经病变进行了研究。采用免疫荧光法以及电子显微镜下的辣根过氧化物酶免疫标记法。指出了神经束膜下免疫球蛋白沉积的直接致病作用。讨论了重链单克隆免疫球蛋白与淀粉样原纤维的关系。

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