Laboratory of Molecular Genetics, Section of Clinical Pharmacology, Department of Neuroscience B.B. Brodie, University of Cagliari, Sp 8, Sestu-Monserrato, Cagliari, Italy.
Eur Psychiatry. 2011 Apr;26(3):141-3. doi: 10.1016/j.eurpsy.2010.09.013. Epub 2011 Feb 2.
Bipolar disorder (BD) is a highly heterogeneous and heritable psychiatric illness. Age at onset has been shown to be a powerful tool for dissecting both the phenotypic and genetic complexity of BD. In this article, we present findings from an association study between the DRD2 TaqIA polymorphism and age at onset, showing that both alleles and genotypes at this locus associate with early onset BD.
双相情感障碍（BD）是一种高度异质且具有遗传性的精神疾病。发病年龄已被证明是剖析BD 的表型和遗传复杂性的有力工具。在本文中，我们报告了 DRD2 TaqIA 多态性与发病年龄之间的关联研究结果，表明该基因座的两个等位基因和基因型均与 BD 的早发有关。
