基因定位与表达。
Gene positioning and expression.
机构信息
Department of Molecular Biosciences, Northwestern University, Evanston, IL, USA.
出版信息
Curr Opin Cell Biol. 2011 Jun;23(3):338-45. doi: 10.1016/j.ceb.2011.01.001. Epub 2011 Feb 1.
Abstract
Within the nucleus, the genome is spatially organized. Individual chromosomes are non-randomly positioned with respect to each other and with respect to nuclear landmarks [1,2]. Furthermore, the position of individual genes can reflect their expression. Here we discuss two well-characterized examples of gene relocalization associated with transcriptional activation: 1) developmentally regulated genes that move from the nuclear periphery to transcription factories in the nucleoplasm upon induction and 2) genes that are targeted from the nucleoplasm to the nuclear periphery, through interactions with the nuclear pore complex (NPC), upon activation. Finally, we speculate as to the mechanistic and functional commonalities of these phenomena.
摘要
在核内，基因组进行空间组织。单个染色体相对于彼此以及相对于核标记物[1,2]是非随机定位的。此外，单个基因的位置可以反映其表达情况。在这里，我们讨论两个与转录激活相关的基因重定位的典型例子：1）发育调控基因，在诱导时从核周移动到核质中的转录工厂；2）基因通过与核孔复合物（NPC）相互作用，从核质靶向到核周，在激活时。最后，我们推测这些现象在机制和功能上具有共性。
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